General Structure Information
| PDB ID | 1pja |
| HGNC Gene Label(s) | PPT2 |
| Structure Name | the crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (ppt1 and ppt2) |
| Resolution | 2.7Å |
| Reference | AUTH G.CALERO,P.GUPTA,M.C.NONATO,S.TANDEL,E.R.BIEHL,S.L.HOFMANN,AUTH 2 J.CLARDYTITL THE CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE-2TITL 2 (PPT2) REVEALS THE BASIS FOR DIVERGENT SUBSTRATETITL 3 SPECIFICITIES OF THE TWO LYSOSOMAL THIOESTERASES, PPT1 ANDTITL 4 PPT2.REF J.BIOL.CHEM. V. 278 37957 2003REFN ISSN 0021-9258PMID 12855696DOI 10.1074/JBC.M301225200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 268 |
| Number Of SNVs | 46 |
| Number Of Permutations | 18202 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.071 |
| p-value | 0.034 |
COSMIC
| Number Of Residues | 268 |
| Number Of SNVs | 3 |
| Number Of Permutations | 252 |
| Optimal Distance Threshold | 40.0 |
| K Statistic | 0.667 |
| p-value | 0.194 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.37 |
| p-value | 0.379 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
