Assessment of Structural Intolerance and Durability
General Structure Information 2a8j TASP1 crystal structure of human taspase1 (acivated form) 1.9Å AUTH J.A.KHAN,B.M.DUNN,L.TONGTITL CRYSTAL STRUCTURE OF HUMAN TASPASE1, A CRUCIALTITL 2 PROTEASE REGULATING THE FUNCTION OF MLL.REF STRUCTURE V. 13 1443 2005REFN ISSN 0969-2126PMID 16216576DOI 10.1016/J.STR.2005.07.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ohf OLA1 crystal structure of human ola1 in complex with amppcp 2.7Å AUTH R.KOLLER-EICHHORN,T.MARQUARDT,R.GAIL,A.WITTINGHOFER,AUTH 2 D.KOSTREWA,U.KUTAY,C.KAMBACHTITL HUMAN OLA1 DEFINES AN ATPASE SUBFAMILY IN THE OBG FAMILY OFTITL 2 GTP-BINDING PROTEINSREF J.BIOL.CHEM. V. 282 19928 2007REFN ISSN 0021-9258PMID 17430889DOI 10.1074/JBC.M700541200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 1wrm DUSP22 crystal structure of jsp-1 1.5Å AUTH T.YOKOTA,Y.NARA,A.KASHIMA,K.MATSUBARA,S.MISAWA,AUTH 2 R.KATO,S.SUGIOTITL CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITYTITL 2 PHOSPHATASE, JNK STIMULATORY PHOSPHATASE-1, AT 1.5TITL 3 A RESOLUTIONREF PROTEINS V. 66 272 2006REFN ISSN 0887-3585PMID 17068812DOI 10.1002/PROT.21152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f0x ACOT13 crystal structure and function of human thioesterase superfamily member 2(them2) 2.3Å AUTH Z.CHENG,F.SONG,X.SHAN,Z.WEI,Y.WANG,AUTH 2 D.DUNAWAY-MARIANO,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN THIOESTERASETITL 2 SUPERFAMILY MEMBER 2REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 349 172 2006REFN ISSN 0006-291XPMID 16934754DOI 10.1016/J.BBRC.2006.08.025 Variant Set Distributions Mapped Variants
General Structure Information 1z4k NT5M structure of the d41n variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 3- monophosphate 1.75Å AUTH K.WALLDEN,B.RUZZENENTE,A.RINALDO-MATTHIS,V.BIANCHI,AUTH 2 P.NORDLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY OF THETITL 2 HUMAN MITOCHONDRIAL DEOXYRIBONUCLEOTIDASEREF STRUCTURE V. 13 1081 2005REFN ISSN 0969-2126PMID 16004879DOI 10.1016/J.STR.2005.04.023 Variant Set Distributions Mapped Variants
General Structure Information 2xsw INPP5E crystal structure of human inpp5e 1.9Å AUTH L.TRESAUGUES,P.SCHUTZ,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN INPP5EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yz4 DUSP15 crystal structure of dusp15 2.4Å AUTH T.S.YOON,D.G.JEONG,J.H.KIM,Y.H.CHO,J.H.SON,J.W.LEE,AUTH 2 S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 VHY, A DUAL-SPECIFICITY PROTEIN PHOSPHATASEREF PROTEINS V. 61 694 2005REFN ISSN 0887-3585PMID 16170801DOI 10.1002/PROT.20642 Variant Set Distributions Mapped Variants
General Structure Information 3rau PTPN23 crystal structure of the hd-ptp bro1 domain 1.95Å AUTH P.SETTE,R.MU,V.DUSSUPT,J.JIANG,G.SNYDER,P.SMITH,T.S.XIAO,AUTH 2 F.BOUAMRTITL THE PHE105 LOOP OF ALIX BRO1 DOMAIN PLAYS A KEY ROLE INTITL 2 HIV-1 RELEASE.REF STRUCTURE V. 19 1485 2011REFN ISSN 0969-2126PMID 21889351DOI 10.1016/J.STR.2011.07.016 Variant Set Distributions Mapped Variants
General Structure Information 3dzx TBC1D22B crystal structure of the rabgap domain of human tbc1d22b 2.3Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,Y.SHEN,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF HUMAN TBC1D22BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants