Assessment of Structural Intolerance and Durability
General Structure Information 1awb IMPA1 human myo-inositol monophosphatase in complex with d- inositol-1-phosphate and calcium 2.5Å AUTH A.J.GANZHORN,J.-M.RONDEAUTITL STRUCTURE OF AN ENZYME-SUBSTRATE COMPLEX AND THETITL 2 CATALYTIC MECHANISM OF HUMAN BRAIN MYO-INOSITOLTITL 3 MONOPHOSPHATASEREF PROTEIN ENG. V. 10 61 1997REFN ISSN 0269-2139 Variant Set Distributions Mapped Variants
General Structure Information 2c0y CTSS the crystal structure of a cys25ala mutant of human procathepsin s 2.1Å AUTH G.KAULMANN,G.J.PALM,K.SCHILLING,R.HILGENFELD,AUTH 2 B.WIEDERANDERSTITL THE CRYSTAL STRUCTURE OF A CYS25 -> ALA MUTANT OFTITL 2 HUMAN PROCATHEPSIN S ELUCIDATES ENZYME-PROSEQUENCETITL 3 INTERACTIONS.REF PROTEIN SCI. V. 15 2619 2006REFN ISSN 0961-8368PMID 17075137DOI 10.1110/PS.062401806 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2x8b ACHE crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-ii 2.95Å AUTH E.CARLETTI,J.P.COLLETIER,F.DUPEUX,M.TROVASLET,AUTH 2 P.MASSON,F.NACHONTITL STRUCTURAL EVIDENCE THAT HUMANTITL 2 ACETYLCHOLINESTERASE INHIBITED BY TABUN AGESTITL 3 THROUGH O-DEALKYLATIONREF J.MED.CHEM. V. 53 4002 2010REFN ISSN 0022-2623PMID 20408548DOI 10.1021/JM901853B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2dlh PTPRD solution structure of the second fn3 domain of human receptor-type tyrosine-protein phosphatase delta -1.0Å AUTH K.SEIMIYA,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASETITL 3 DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ifv CDC25B crystal structure of an active site mutant, c473d, of cdc25b phosphatase catalytic domain 1.6Å AUTH J.SOHN,G.BUHRMAN,J.RUDOLPHTITL KINETIC AND STRUCTURAL STUDIES OF SPECIFICTITL 2 PROTEIN-PROTEIN INTERACTIONS IN SUBSTRATETITL 3 CATALYSIS BY CDC25B PHOSPHATASE.REF BIOCHEMISTRY V. 46 807 2007REFN ISSN 0006-2960PMID 17223702DOI 10.1021/BI061257Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2nlk PTPRG crystal structure of d1 and d2 catalytic domains of human protein tyrosine phosphatase gamma (d1+d2 ptprg) 2.4Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3qak ADORA2A agonist bound structure of the human adenosine a2a receptor 2.71Å AUTH F.XU,H.WU,V.KATRITCH,G.W.HAN,K.A.JACOBSON,Z.G.GAO,AUTH 2 V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF AN AGONIST-BOUND HUMAN A2A ADENOSINE RECEPTOR.REF SCIENCE V. 332 322 2011REFN ISSN 0036-8075PMID 21393508DOI 10.1126/SCIENCE.1202793 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zjd TNFAIP3 a20 otu domain in reduced, active state at 1.87 a resolution 1.87Å AUTH Y.KULATHU,F.J.GARCIA,T.E.T.MEVISSEN,M.BUSCH,N.ARNAUDO,AUTH 2 K.S.CARROLL,D.BARFORD,D.KOMANDERTITL REGULATION OF A20 AND OTHER OTU DEUBIQUITINASES BYTITL 2 REVERSIBLE OXIDATIONREF NAT.COMMUN. V. 4 1569 2013REFN ISSN 2041-1723PMID 23463012DOI 10.1038/NCOMMS2567 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2eqe TNFAIP3 solution structure of the fourth a20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 -1.0Å AUTH H.P.ZHANG,T.NAGASIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH A20-TYPE ZINCTITL 2 FINGER DOMAIN FROM HUMAN TUMOR NECROSIS FACTOR,TITL 3 ALPHA-INDUCED PROTEIN3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1fuj PRTN3 pr3 (myeloblastin) 2.2Å AUTH M.FUJINAGA,M.M.CHERNAIA,R.HALENBECK,K.KOTHS,M.N.JAMESTITL THE CRYSTAL STRUCTURE OF PR3, A NEUTROPHIL SERINE PROTEINASETITL 2 ANTIGEN OF WEGENERS GRANULOMATOSIS ANTIBODIES.REF J.MOL.BIOL. V. 261 267 1996REFN ISSN 0022-2836PMID 8757293DOI 10.1006/JMBI.1996.0458 Variant Set Distributions Mapped Variants