Assessment of Structural Intolerance and Durability
General Structure Information 3jxh PTPRG ca-like domain of human ptprg 1.7Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3tk9 GZMH crystal structure of human granzyme h 2.2Å AUTH L.WANG,K.ZHANG,L.WU,S.LIU,H.ZHANG,Q.ZHOU,L.TONG,F.SUN,Z.FANTITL STRUCTURAL INSIGHTS INTO THE SUBSTRATE SPECIFICITY OF HUMANTITL 2 GRANZYME H: THE FUNCTIONAL ROLES OF A NOVEL RKR MOTIFREF J.IMMUNOL. V. 188 765 2012REFN ISSN 0022-1767PMID 22156497DOI 10.4049/JIMMUNOL.1101381 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v2w S1PR1 crystal structure of a lipid g protein-coupled receptor at 3.35a 3.35Å AUTH M.A.HANSON,C.B.ROTH,E.JO,M.T.GRIFFITH,F.L.SCOTT,G.REINHART,AUTH 2 H.DESALE,B.CLEMONS,S.M.CAHALAN,S.C.SCHUERER,M.G.SANNA,AUTH 3 G.W.HAN,P.KUHN,H.ROSEN,R.C.STEVENSTITL CRYSTAL STRUCTURE OF A LIPID G PROTEIN-COUPLED RECEPTOR.REF SCIENCE V. 335 851 2012REFN ISSN 0036-8075PMID 22344443DOI 10.1126/SCIENCE.1215904 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2b49 PTPN3 crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3 1.54Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jjd PTPRE protein tyrosine phosphatase, receptor type, e isoform 3.2Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4awn DNASE1 structure of recombinant human dnase i (rhdnasei) in complex with magnesium and phosphate. 1.95Å AUTH G.PARSIEGLA,C.NOGUERE,L.SANTELL,R.A.LAZARUS,Y.BOURNETITL THE STRUCTURE OF HUMAN DNASE I BOUND TO MAGNESIUM ANDTITL 2 PHOSPHATE IONS POINTS TO A CATALYTIC MECHANISM COMMON TOTITL 3 MEMBERS OF THE DNASE I-LIKE SUPERFAMILY.REF BIOCHEMISTRY V. 51 10250 2012REFN ISSN 0006-2960PMID […]
General Structure Information 1apy AGA human aspartylglucosaminidase 2.0Å AUTH C.OINONEN,R.TIKKANEN,J.ROUVINEN,L.PELTONENTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMALTITL 2 ASPARTYLGLUCOSAMINIDASE.REF NAT.STRUCT.BIOL. V. 2 1102 1995REFN ISSN 1072-8368PMID 8846222DOI 10.1038/NSB1295-1102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1apy AGA human aspartylglucosaminidase 2.0Å AUTH C.OINONEN,R.TIKKANEN,J.ROUVINEN,L.PELTONENTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMALTITL 2 ASPARTYLGLUCOSAMINIDASE.REF NAT.STRUCT.BIOL. V. 2 1102 1995REFN ISSN 1072-8368PMID 8846222DOI 10.1038/NSB1295-1102 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yd6 PTPRD crystal structure of the n-terminal ig1-2 module of human receptor protein tyrosine phosphatase delta 1.35Å AUTH C.H.COLES,Y.SHEN,A.P.TENNEY,C.SIEBOLD,G.C.SUTTON,W.LU,AUTH 2 J.T.GALLAGHER,E.Y.JONES,J.G.FLANAGAN,A.R.ARICESCUTITL PROTEOGLYCAN-SPECIFIC MOLECULAR SWITCH FOR RPTP SIGMATITL 2 CLUSTERING AND NEURONAL EXTENSION.REF SCIENCE V. 332 484 2011REFN ISSN 0036-8075PMID 21454754DOI 10.1126/SCIENCE.1200840 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3op3 CDC25C crystal structure of cell division cycle 25c protein isoform a from homo sapiens 2.63Å AUTH Y.KIM,A.WEGER,C.HATZOS,P.SAVITSKY,C.JOHANSSON,L.BALL,A.BARR,AUTH 2 M.VOLLMAR,J.MUNIZ,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,O.GILEADI,F.VON DELFT,S.KNAPP,A.JOACHIMIAKTITL CRYSTAL STRUCTURE OF CELL DIVISION CYCLE 25C PROTEIN ISOFORMTITL 2 A FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants