Assessment of Structural Intolerance and Durability
General Structure Information 1c25 CDC25A human cdc25a catalytic domain 2.3Å AUTH E.B.FAUMAN,J.P.COGSWELL,B.LOVEJOY,W.J.ROCQUE,AUTH 2 W.HOLMES,V.G.MONTANA,H.PIWNICA-WORMS,M.J.RINK,AUTH 3 M.A.SAPERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THETITL 2 HUMAN CELL CYCLE CONTROL PHOSPHATASE, CDC25A.REF CELL(CAMBRIDGE,MASS.) V. 93 617 1998REFN ISSN 0092-8674PMID 9604936DOI 10.1016/S0092-8674(00)81190-3 Variant Set Distributions Mapped Variants
General Structure Information 1x5z PTPRD solution structure of the fibronectin type-iii domain of human protein tyrosine phosphatase, receptor type, d isoform 4 variant -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIBRONECTIN TYPE-IIITITL 2 DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE,TITL 3 RECEPTOR TYPE, D ISOFORM 4 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4c6f CAD crystal structure of the dihydroorotase domain of human cad bound to substrate at ph 6.5 1.26Å AUTH A.GRANDE-GARCIA,N.LALLOUS,C.DIAZ-TEJADA,S.RAMON-MAIQUESTITL STRUCTURE, FUNCTIONAL CHARACTERIZATION AND EVOLUTION OF THETITL 2 DIHYDROOROTASE DOMAIN OF HUMAN CAD.REF STRUCTURE V. 22 185 2014REFN ISSN 0969-2126PMID 24332717DOI 10.1016/J.STR.2013.10.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3jxf PTPRZ1 ca-like domain of human ptprz 2.0Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dzf CD38 crystal structure of human cd38 extracellular domain complexed with a covalent intermediate, ara-f-ribose-5-phosphate 2.01Å AUTH Q.LIU,I.A.KRIKSUNOV,H.JIANG,R.GRAEFF,H.LIN,H.C.LEE,Q.HAOTITL COVALENT AND NONCOVALENT INTERMEDIATES OF AN NAD UTILIZINGTITL 2 ENZYME, HUMAN CD38.REF CHEM.BIOL. V. 15 1068 2008REFN ISSN 1074-5521PMID 18940667DOI 10.1016/J.CHEMBIOL.2008.08.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3i8v PDE4A crystal structure of human pde4a with 4-(3-butoxy-4-methoxyphenyl) methyl-2-imidazolidone 2.25Å AUTH R.K.Y.CHENG,L.CRAWLEY,J.BARKER,M.WOOD,B.FELICETTI,AUTH 2 M.WHITTAKERTITL CRYSTAL STRUCTURE OF HUMAN PDE4A WITHTITL 2 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1a7a AHCY structure of human placental s-adenosylhomocysteine hydrolase: determination of a 30 selenium atom substructure from data at a single wavelength 2.8Å AUTH M.A.TURNER,C.S.YUAN,R.T.BORCHARDT,M.S.HERSHFIELD,G.D.SMITH,AUTH 2 P.L.HOWELLTITL STRUCTURE DETERMINATION OF SELENOMETHIONYLTITL 2 S-ADENOSYLHOMOCYSTEINE HYDROLASE USING DATA AT A SINGLETITL 3 WAVELENGTH.REF NAT.STRUCT.BIOL. V. 5 369 1998REFN ISSN 1072-8368PMID 9586999DOI 10.1038/NSB0598-369 Variant Set Distributions […]
General Structure Information 3dpe MMP8 crystal structure of the complex between mmp-8 and a non- zinc chelating inhibitor 1.6Å AUTH G.POCHETTI,R.MONTANARI,C.GEGE,C.CHEVRIER,AUTH 2 A.G.TAVERAS,F.MAZZATITL EXTRA BINDING REGION INDUCED BY NON-ZINC CHELATINGTITL 2 INHIBITORS INTO THE S(1) SUBSITE OF MATRIXTITL 3 METALLOPROTEINASE 8 (MMP-8)REF J.MED.CHEM. V. 52 1040 2009REFN ISSN 0022-2623PMID 19173605DOI 10.1021/JM801166J Variant Set Distributions Ripley’s […]
General Structure Information 4h1y NT5E human ecto-5-nucleotidase (cd73): crystal form ii (open) in complex with psb11552 1.58Å AUTH K.KNAPP,M.ZEBISCH,J.PIPPEL,A.EL-TAYEB,C.E.MULLER,N.STRATERTITL CRYSTAL STRUCTURE OF THE HUMAN ECTO-5-NUCLEOTIDASE (CD73):TITL 2 INSIGHTS INTO THE REGULATION OF PURINERGIC SIGNALING.REF STRUCTURE V. 20 2161 2012REFN ISSN 0969-2126PMID 23142347DOI 10.1016/J.STR.2012.10.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants