Assessment of Structural Intolerance and Durability
General Structure Information 2gwf USP8 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Mapped Variants
General Structure Information 1mx1 CES1 crystal structure of human liver carboxylesterase in complex with tacrine 2.4Å AUTH S.BENCHARIT,C.L.MORTON,J.L.HYATT,P.KUHN,M.K.DANKS,AUTH 2 P.M.POTTER,M.R.REDINBOTITL CRYSTAL STRUCTURE OF HUMAN CARBOXYLESTERASE 1 COMPLEXED WITHTITL 2 THE ALZHEIMERS DRUG TACRINE: FROM BINDING PROMISCUITY TOTITL 3 SELECTIVE INHIBITIONREF CHEM.BIOL. V. 10 341 2003REFN ISSN 1074-5521PMID 12725862DOI 10.1016/S1074-5521(03)00071-1 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3e4c CASP1 procaspase-1 zymogen domain crystal strucutre 2.05Å AUTH J.M.ELLIOTT,L.ROUGE,C.WIESMANN,J.M.SCHEERTITL CRYSTAL STRUCTURE OF PROCASPASE-1 ZYMOGEN DOMAIN REVEALSTITL 2 INSIGHT INTO INFLAMMATORY CASPASE AUTOACTIVATIONREF J.BIOL.CHEM. V. 284 6546 2009REFN ISSN 0021-9258PMID 19117953DOI 10.1074/JBC.M806121200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nn6 CMA1 human pro-chymase 1.75Å AUTH K.K.REILING,J.KRUCINSKI,L.J.MIERCKE,W.W.RAYMOND,G.H.CAUGHEY,AUTH 2 R.M.STROUDTITL STRUCTURE OF HUMAN PRO-CHYMASE: A MODEL FOR THE ACTIVATINGTITL 2 TRANSITION OF GRANULE-ASSOCIATED PROTEASES.REF BIOCHEMISTRY V. 42 2616 2003REFN ISSN 0006-2960PMID 12614156DOI 10.1021/BI020594D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1rpm PTPRM human receptor protein tyrosine phosphatase mu, domain 1 2.3Å AUTH K.M.HOFFMANN,N.K.TONKS,D.BARFORDTITL THE CRYSTAL STRUCTURE OF DOMAIN 1 OF RECEPTORTITL 2 PROTEIN-TYROSINE PHOSPHATASE MU.REF J.BIOL.CHEM. V. 272 27505 1997REFN ISSN 0021-9258PMID 9346878DOI 10.1074/JBC.272.44.27505 Variant Set Distributions Mapped Variants
General Structure Information 2vph PTPN4 crystal structure of the human protein tyrosine phosphatase, non-receptor type 4, pdz domain 1.9Å AUTH A.K.ROOS,J.WANG,N.BURGESS-BROWN,J.M.ELKINS,K.KAVANAGH,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,F.VON DELFT,C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE, NON-RECEPTOR TYPE 4, PDZ DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hc2 PTPRB engineered protein tyrosine phosphatase beta catalytic domain 1.4Å AUTH A.G.EVDOKIMOV,M.POKROSS,R.WALTER,M.MEKEL,B.COX,AUTH 2 C.LI,R.BECHARD,F.GENBAUFFE,R.ANDREWS,C.DIVEN,AUTH 3 B.HOWARD,V.RASTOGI,J.GRAY,M.MAIER,K.G.PETERSTITL ENGINEERING THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 TYROSINE PHOSPHATASE BETA FOR STRUCTURE-BASED DRUGTITL 3 DISCOVERY.REF ACTA CRYSTALLOGR.,SECT.D V. 62 1435 2006REFN ISSN 0907-4449PMID 17139078DOI 10.1107/S0907444906037784 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ps5 PTPN6 crystal structure of the full-length human protein tyrosine phosphatase shp-1 3.1Å AUTH W.WANG,L.LIU,X.SONG,Y.MO,C.KOMMA,H.D.BELLAMY,Z.J.ZHAO,AUTH 2 G.W.ZHOUTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASETITL 2 SHP-1 IN THE OPEN CONFORMATION.REF J.CELL.BIOCHEM. V. 112 2062 2011REFN ISSN 0730-2312PMID 21465528DOI 10.1002/JCB.23125 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2oph DPP4 human dipeptidyl peptidase iv in complex with an alpha amino acid inhibitor 2.4Å AUTH J.L.DUFFY,B.A.KIRK,L.WANG,G.J.EIERMANN,H.HE,B.LEITING,AUTH 2 K.A.LYONS,R.A.PATEL,S.B.PATEL,A.PETROV,G.SCAPIN,J.K.WU,AUTH 3 N.A.THORNBERRY,A.E.WEBERTITL 4-AMINOPHENYLALANINE AND 4-AMINOCYCLOHEXYLALANINETITL 2 DERIVATIVES AS POTENT, SELECTIVE, AND ORALLY BIOAVAILABLETITL 3 INHIBITORS OF DIPEPTIDYL PEPTIDASE IV.REF BIOORG.MED.CHEM.LETT. V. 17 2879 2007REFN ISSN 0960-894XPMID 17350841DOI 10.1016/J.BMCL.2007.02.066 Variant Set Distributions Ripley’s K […]
General Structure Information 3n8i ACP1 crystal structure of the a isoform of human cytoplasmic protein tyrosine phosphatase (hcptp-a) in complex with 1-naphtylacetic acid 1.5Å AUTH K.T.HOMAN,D.BALASUBRAMANIAM,C.V.STAUFFACHERTITL STRUCTURAL CHARACTERIZATION OF A SECONDARY BINDING SITE ONTITL 2 LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]