Assessment of Structural Intolerance and Durability
General Structure Information 2lqb ATP7B metal binding repeat 2 of the wilson disease protein (atp7b) -1.0Å AUTH N.V.DOLGOVA,S.NOKHRIN,C.H.YU,G.N.GEORGE,O.Y.DMITRIEVTITL COPPER CHAPERONE ATOX1 INTERACTS WITH THE METAL-BINDINGTITL 2 DOMAIN OF WILSONS DISEASE PROTEIN IN CISPLATINTITL 3 DETOXIFICATION.REF BIOCHEM.J. V. 454 147 2013REFN ISSN 0264-6021PMID 23751120DOI 10.1042/BJ20121656 Variant Set Distributions Mapped Variants
General Structure Information 3otq EPHX2 soluble epoxide hydrolase in complex with pyrazole antagonist 3.0Å AUTH H.Y.LO,C.C.MAN,R.W.FLECK,N.A.FARROW,R.H.INGRAHAM,A.KUKULKA,AUTH 2 J.R.PROUDFOOT,R.BETAGERI,T.KIRRANE,U.PATEL,R.SHARMA,AUTH 3 M.A.HOERMANN,A.KABCENELL,S.D.LOMBAERTTITL SUBSTITUTED PYRAZOLES AS NOVEL SEH ANTAGONIST: INVESTIGATIONTITL 2 OF KEY BINDING INTERACTIONS WITHIN THE CATALYTIC DOMAIN.REF BIOORG.MED.CHEM.LETT. V. 20 6379 2010REFN ISSN 0960-894XPMID 20934334DOI 10.1016/J.BMCL.2010.09.095 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2rnf RNASE4 x-ray crystal structure of human ribonuclease 4 in complex with d(up) 2.4Å AUTH S.S.TERZYAN,R.PERACAULA,R.DE LLORENS,Y.TSUSHIMA,AUTH 2 H.YAMADA,M.SENO,F.X.GOMIS-RUTH,M.COLLTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMAN RNASE 4,TITL 2 UNLIGANDED AND COMPLEXED WITH D(UP), REVEALS THETITL 3 BASIS FOR ITS URIDINE SELECTIVITY.REF J.MOL.BIOL. V. 285 205 1999REFN ISSN 0022-2836PMID 9878400DOI 10.1006/JMBI.1998.2288 Variant Set Distributions […]
General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]
General Structure Information 2wwy RECQL structure of human recq-like helicase in complex with a dna substrate 2.9Å AUTH A.C.W.PIKE,Y.ZHANG,C.SCHNECKE,A.CHAIKUAD,T.KROJER,AUTH 2 C.D.O.COOPER,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,C.BOUNTRA,O.GILEADITITL RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCHTITL 2 MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURESREF PROC.NATL.ACAD.SCI.USA V. 112 4286 2015REFN ISSN 0027-8424PMID 25831490DOI 10.1073/PNAS.1417594112 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3rze HRH1 structure of the human histamine h1 receptor in complex with doxepin 3.1Å AUTH T.SHIMAMURA,M.SHIROISHI,S.WEYAND,H.TSUJIMOTO,G.WINTER,AUTH 2 V.KATRITCH,R.ABAGYAN,V.CHEREZOV,W.LIU,G.W.HAN,T.KOBAYASHI,AUTH 3 R.C.STEVENS,S.IWATATITL STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR COMPLEX WITHTITL 2 DOXEPIN.REF NATURE V. 475 65 2011REFN ISSN 0028-0836PMID 21697825DOI 10.1038/NATURE10236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 7pck CTSK crystal structure of wild type human procathepsin k 3.2Å AUTH J.SIVARAMAN,M.LALUMIERE,R.MENARD,M.CYGLERTITL CRYSTAL STRUCTURE OF WILD-TYPE HUMAN PROCATHEPSINTITL 2 K.REF PROTEIN SCI. V. 8 283 1999REFN ISSN 0961-8368PMID 10048321 Variant Set Distributions Mapped Variants
General Structure Information 2i3c ASPA crystal structure of an aspartoacylase from homo sapiens 2.8Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,J.G.MCCOY,AUTH 2 G.N.PHILLIPSTITL STRUCTURE OF ASPARTOACYLASE, THE BRAIN ENZYMETITL 2 IMPAIRED IN CANAVAN DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 104 456 2007REFN ISSN 0027-8424PMID 17194761DOI 10.1073/PNAS.0607817104 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4djh OPRK1 structure of the human kappa opioid receptor in complex with jdtic 2.9Å AUTH H.WU,D.WACKER,M.MILENI,V.KATRITCH,G.W.HAN,E.VARDY,W.LIU,AUTH 2 A.A.THOMPSON,X.P.HUANG,F.I.CARROLL,S.W.MASCARELLA,AUTH 3 R.B.WESTKAEMPER,P.D.MOSIER,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL TRUCTURE OF THE HUMAN KAPPA-OPIOID RECEPTOR IN COMPLEX WITHTITL 2 JDTICREF NATURE V. 485 327 2012REFN ISSN 0028-0836PMID 22437504DOI 10.1038/NATURE10939 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1fb1 GCH1 crystal structure of human gtp cyclohydrolase i 3.1Å AUTH G.AUERBACH,A.HERRMANN,A.BRACHER,G.BADER,M.GUTLICH,M.FISCHER,AUTH 2 M.NEUKAMM,M.GARRIDO-FRANCO,J.RICHARDSON,H.NAR,R.HUBER,AUTH 3 A.BACHERTITL ZINC PLAYS A KEY ROLE IN HUMAN AND BACTERIAL GTPTITL 2 CYCLOHYDROLASE I.REF PROC.NATL.ACAD.SCI.USA V. 97 13567 2000REFN ISSN 0027-8424PMID 11087827DOI 10.1073/PNAS.240463497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]