Assessment of Structural Intolerance and Durability
General Structure Information 3fxm PPM1A crystal structure of human protein phosphatase 1a (ppm1a) bound with citrate at 10 mm of mn2+ 2.5Å AUTH T.HU,L.WANG,K.WANG,J.CHEN,H.JIANG,X.SHENTITL STRUCTURAL BASIS FOR THE MN2+-DEPENDENT ACTIVATIONTITL 2 OF HUMAN PPM1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3n2z PRCP the structure of human prolylcarboxypeptidase at 2.80 angstroms resolution 2.79Å AUTH S.M.SOISSON,S.B.PATEL,P.D.ABEYWICKREMA,N.J.BRYNE,R.E.DIEHL,AUTH 2 D.L.HALL,R.E.FORD,J.C.REID,K.W.RICKERT,J.M.SHIPMAN,S.SHARMA,AUTH 3 K.J.LUMBTITL STRUCTURAL DEFINITION AND SUBSTRATE SPECIFICITY OF THE S28TITL 2 PROTEASE FAMILY: THE CRYSTAL STRUCTURE OF HUMANTITL 3 PROLYLCARBOXYPEPTIDASE.REF BMC STRUCT.BIOL. V. 10 16 2010REFN ESSN 1472-6807PMID 20540760DOI 10.1186/1472-6807-10-16 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4b3f IGHMBP2 crystal structure of 1ghmbp2 helicase 2.5Å AUTH S.C.LIM,M.W.BOWLER,T.F.LAI,H.SONGTITL THE IGHMBP2 HELICASE STRUCTURE REVEALS THE MOLECULAR BASISTITL 2 FOR DISEASE-CAUSING MUTATIONS IN DMSA1.REF NUCLEIC ACIDS RES. V. 40 11009 2012REFN ISSN 0305-1048PMID 22965130DOI 10.1093/NAR/GKS792 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1mq0 CDA crystal structure of human cytidine deaminase 2.4Å AUTH S.J.CHUNG,J.C.FROMME,G.L.VERDINETITL STRUCTURE OF HUMAN CYTIDINE DEAMINASE BOUND TO A POTENTTITL 2 INHIBITORREF J.MED.CHEM. V. 48 658 2005REFN ISSN 0022-2623PMID 15689149DOI 10.1021/JM0496279 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lrr IGHMBP2 solution structure of the r3h domain from human smubp-2 in complex with 2-deoxyguanosine-5-monophosphate -1.0Å AUTH K.JAUDZEMS,X.JIA,H.YAGI,D.ZHULENKOVS,B.GRAHAM,G.OTTING,AUTH 2 E.LIEPINSHTITL STRUCTURAL BASIS FOR 5-END-SPECIFIC RECOGNITION OFTITL 2 SINGLE-STRANDED DNA BY THE R3H DOMAIN FROM HUMAN SMUBP-2REF J.MOL.BIOL. V. 12 760 2012REFN ISSN 0022-2836PMID 22999958DOI 10.1016/J.JMB.2012.09.010 Variant Set Distributions Mapped Variants
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2koy ATP7B structure of the e1064a mutant of the n-domain of wilson disease associated protein -1.0Å AUTH O.Y.DMITRIEV,S.L.LUTSENKO,E.E.UHLEMANNTITL THE STRUCTURE OF THE E1064A MUTANT REVEALS ATP-DEPENDENTTITL 2 CONFORMATIONAL CHANGES IN THE ATP7B N-DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3cki TIMP3 crystal structure of the tace-n-timp-3 complex 2.3Å AUTH M.WISNIEWSKA,P.GOETTIG,K.MASKOS,E.BELOUSKI,AUTH 2 D.WINTERS,R.HECHT,R.BLACK,W.BODETITL STRUCTURAL DETERMINANTS OF THE ADAM INHIBITION BYTITL 2 TIMP-3: CRYSTAL STRUCTURE OF THE TACE-N-TIMP-3TITL 3 COMPLEX.REF J.MOL.BIOL. V. 381 1307 2008REFN ISSN 0022-2836PMID 18638486DOI 10.1016/J.JMB.2008.06.088 Variant Set Distributions Mapped Variants
General Structure Information 2bcd PPP1CC x-ray crystal structure of protein phosphatase-1 with the marine toxin motuporin bound 2.1Å AUTH J.T.MAYNES,H.A.LUU,M.M.CHERNEY,R.J.ANDERSEN,D.WILLIAMS,AUTH 2 C.F.HOLMES,M.N.JAMESTITL CRYSTAL STRUCTURES OF PROTEIN PHOSPHATASE-1 BOUND TOTITL 2 MOTUPORIN AND DIHYDROMICROCYSTIN-LA: ELUCIDATION OF THETITL 3 MECHANISM OF ENZYME INHIBITION BY CYANOBACTERIAL TOXINS.REF J.MOL.BIOL. V. 356 111 2006REFN ISSN 0022-2836PMID 16343532DOI 10.1016/J.JMB.2005.11.019 Variant Set […]