Assessment of Structural Intolerance and Durability
General Structure Information 2qfz TBC1D22A crystal structure of human tbc1 domain family member 22a 2.1Å AUTH Y.TONG,W.TEMPEL,S.DIMOV,A.DONG,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILYTITL 2 MEMBER 22A.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lo6 KLK6 human kallikrein 6 (hk6) active form with benzamidine inhibitor at 1.56 a resolution 1.56Å AUTH M.J.BERNETT,S.I.BLABER,I.A.SCARISBRICK,AUTH 2 P.DHANARAJAN,S.M.THOMPSON,M.BLABERTITL CRYSTAL STRUCTURE AND BIOCHEMICAL CHARACTERIZATIONTITL 2 OF HUMAN KALLIKREIN 6 REVEALS A TRYPSIN-LIKETITL 3 KALLIKREIN IS EXPRESSED IN THE CENTRAL NERVOUSTITL 4 SYSTEMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1tdh NEIL1 crystal structure of human endonuclease viii-like 1 (neil1) 2.1Å AUTH S.DOUBLIE,V.BANDARU,J.P.BOND,S.S.WALLACETITL THE CRYSTAL STRUCTURE OF HUMAN ENDONUCLEASETITL 2 VIII-LIKE 1 (NEIL1) REVEALS A ZINCLESS FINGERTITL 3 MOTIF REQUIRED FOR GLYCOSYLASE ACTIVITY.REF PROC.NATL.ACAD.SCI.USA V. 101 10284 2004REFN ISSN 0027-8424PMID 15232006DOI 10.1073/PNAS.0402051101 Variant Set Distributions Mapped Variants
General Structure Information 2vt8 PSMF1 structure of a conserved dimerisation domain within fbox7 and pi31 2.6Å AUTH R.J.KIRK,H.LAMAN,P.P.KNOWLES,J.MURRAY-RUST,AUTH 2 M.LOMONOSOV,E.K.MEZIANE,N.Q.MCDONALDTITL STRUCTURE OF A CONSERVED DIMERIZATION DOMAINTITL 2 WITHIN THE F-BOX PROTEIN FBXO7 AND THE PI31TITL 3 PROTEASOME INHIBITOR.REF J.BIOL.CHEM. V. 283 22325 2008REFN ISSN 0021-9258PMID 18495667DOI 10.1074/JBC.M709900200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2m17 UBLCP1 ubiquitin-like domain-containing c-terminal domain phosphatase (ublcp1) -1.0Å AUTH J.H.YUN,S.KO,C.K.LEE,H.K.CHEONG,C.CHEONG,J.B.YOON,W.LEETITL SOLUTION STRUCTURE AND RPN1 INTERACTION OF THE UBL DOMAIN OFTITL 2 HUMAN RNA POLYMERASE II C-TERMINAL DOMAIN PHOSPHATASE.REF PLOS ONE V. 8 62981 2013REFN ESSN 1932-6203PMID 23667555DOI 10.1371/JOURNAL.PONE.0062981 Variant Set Distributions Mapped Variants
General Structure Information 4ido ATL1 human atlastin-1 1-446, c-his6, gdpalf4- 2.09Å AUTH L.J.BYRNES,A.SINGH,K.SZETO,N.M.BENVIN,J.P.ODONNELL,AUTH 2 W.R.ZIPFEL,H.SONDERMANNTITL STRUCTURAL BASIS FOR CONFORMATIONAL SWITCHING AND GTPTITL 2 LOADING OF THE LARGE G PROTEIN ATLASTIN.REF EMBO J. V. 32 369 2013REFN ISSN 0261-4189PMID 23334294DOI 10.1038/EMBOJ.2012.353 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wlj ISG20 human isg20 1.9Å AUTH T.HORIO,M.MURAI,T.INOUE,T.HAMASAKI,T.TANAKA,T.OHGITITL CRYSTAL STRUCTURE OF HUMAN ISG20, ANTITL 2 INTERFERON-INDUCED ANTIVIRAL RIBONUCLEASEREF FEBS LETT. V. 577 111 2004REFN ISSN 0014-5793PMID 15527770DOI 10.1016/J.FEBSLET.2004.09.074 Variant Set Distributions Mapped Variants
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3tjo HTRA1 htra1 catalytic domain, mutationally inactivated 2.3Å AUTH C.EIGENBROT,M.ULTSCH,M.T.LIPARI,P.MORAN,S.J.LIN,R.GANESAN,AUTH 2 C.QUAN,J.TOM,W.SANDOVAL,M.VAN LOOKEREN CAMPAGNE,D.KIRCHHOFERTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF HTRA1 AND ITSTITL 2 SUBDOMAINS.REF STRUCTURE V. 20 1040 2012REFN ISSN 0969-2126PMID 22578544DOI 10.1016/J.STR.2012.03.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3tmo OTUD5 the catalytic domain of human deubiquitinase duba 2.2Å AUTH O.W.HUANG,X.MA,J.YIN,J.FLINDERS,T.MAURER,N.KAYAGAKI,Q.PHUNG,AUTH 2 I.BOSANAC,D.ARNOTT,V.M.DIXIT,S.G.HYMOWITZ,M.A.STAROVASNIK,AUTH 3 A.G.COCHRANTITL PHOSPHORYLATION-DEPENDENT ACTIVITY OF THE DEUBIQUITINASETITL 2 DUBA.REF NAT.STRUCT.MOL.BIOL. V. 19 171 2012REFN ISSN 1545-9993PMID 22245969DOI 10.1038/NSMB.2206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants