General Structure Information
| PDB ID | 3tjo |
| HGNC Gene Label(s) | HTRA1 |
| Structure Name | htra1 catalytic domain, mutationally inactivated |
| Resolution | 2.3Å |
| Reference | AUTH C.EIGENBROT,M.ULTSCH,M.T.LIPARI,P.MORAN,S.J.LIN,R.GANESAN,AUTH 2 C.QUAN,J.TOM,W.SANDOVAL,M.VAN LOOKEREN CAMPAGNE,D.KIRCHHOFERTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF HTRA1 AND ITSTITL 2 SUBDOMAINS.REF STRUCTURE V. 20 1040 2012REFN ISSN 0969-2126PMID 22578544DOI 10.1016/J.STR.2012.03.021 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 196 |
| Number Of SNVs | 37 |
| Number Of Permutations | 31171 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.455 |
| p-value | 0.549 |
ClinVar
| Number Of Residues | 196 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2098 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.4 |
| p-value | 0.102 |
COSMIC
| Number Of Residues | 196 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1896 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.143 |
| p-value | 0.904 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.313 |
| p-value | 0.088 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.154 |
| p-value | 0.602 |