General Structure Information
| PDB ID | 1lo6 |
| HGNC Gene Label(s) | KLK6 |
| Structure Name | human kallikrein 6 (hk6) active form with benzamidine inhibitor at 1.56 a resolution |
| Resolution | 1.56Å |
| Reference | AUTH M.J.BERNETT,S.I.BLABER,I.A.SCARISBRICK,AUTH 2 P.DHANARAJAN,S.M.THOMPSON,M.BLABERTITL CRYSTAL STRUCTURE AND BIOCHEMICAL CHARACTERIZATIONTITL 2 OF HUMAN KALLIKREIN 6 REVEALS A TRYPSIN-LIKETITL 3 KALLIKREIN IS EXPRESSED IN THE CENTRAL NERVOUSTITL 4 SYSTEMREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 213 |
| Number Of SNVs | 61 |
| Number Of Permutations | 19401 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.073 |
| p-value | 0.056 |
COSMIC
| Number Of Residues | 213 |
| Number Of SNVs | 5 |
| Number Of Permutations | 376 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.2 |
| p-value | 0.37 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.279 |
| p-value | 0.637 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
