1TDH.A | NEIL1

General Structure Information

PDB ID	1tdh
HGNC Gene Label(s)	NEIL1
Structure Name	crystal structure of human endonuclease viii-like 1 (neil1)
Resolution	2.1Å
Reference	AUTH S.DOUBLIE,V.BANDARU,J.P.BOND,S.S.WALLACETITL THE CRYSTAL STRUCTURE OF HUMAN ENDONUCLEASETITL 2 VIII-LIKE 1 (NEIL1) REVEALS A ZINCLESS FINGERTITL 3 MOTIF REQUIRED FOR GLYCOSYLASE ACTIVITY.REF PROC.NATL.ACAD.SCI.USA V. 101 10284 2004REFN ISSN 0027-8424PMID 15232006DOI 10.1073/PNAS.0402051101

Variant Set Distributions

ExAC Variants

Number Of Residues	284
Number Of SNVs	96
Number Of Permutations	17114
Optimal Distance Threshold	18.0
K Statistic	0.219
p-value	0.058

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:75641263		E>G	A:6	(21.23, 19.30, 11.92)
15:75641266		L>P	A:7	(23.79, 17.89, 15.38)
15:75641296		A>V	A:17	(10.83, 18.64, 24.65)
15:75641323		C>F	A:26	(12.20, -0.22, 27.78)
15:75641330	COSM964969	E>D	A:28	(11.26, -0.19, 21.99)
15:75641344	rs201878868	S>T	A:33	(18.45, -2.01, 13.49)
15:75641352		P>S	A:36	(23.16, -1.33, 19.36)
15:75641353		P>L	A:36	(23.16, -1.33, 19.36)
15:75641358	rs539217682	V>M	A:38	(19.46, -0.02, 24.77)
15:75641367	rs146988131	E>Q	A:41	(13.85, -1.40, 32.72)
15:75641371		S>N	A:42	(13.10, 3.13, 34.28)
15:75641392	rs184655220	A>G	A:49	(21.12, 16.58, 25.24)
15:75641394		S>T	A:50	(24.71, 17.09, 24.02)
15:75641397		A>T	A:51	(26.42, 18.60, 21.04)
15:75641398		A>V	A:51	(26.42, 18.60, 21.04)
15:75641411		E>D	A:55	(28.94, 13.17, 17.70)
15:75641415		R>C	A:57	(26.39, 13.08, 25.05)
15:75641443		A>V	A:66	(13.02, 4.56, 40.12)
15:75641445	rs566545683	Q>K	A:67	(12.47, 0.76, 40.63)
15:75641449	rs187873972	P>H	A:68	(14.36, -1.06, 38.02)
15:75641454	rs555332483	Q>K	A:70	(19.25, 1.97, 35.66)
15:75641464		L>P	A:73	(22.74, 5.07, 29.63)
15:75641478		R>C	A:78	(27.38, 8.12, 14.13)
15:75641491	rs5745905	S>C	A:82	(18.03, 10.13, 7.13)
15:75641493		G>R	A:83	(18.46, 11.43, 10.52)
15:75641494	rs5745906	G>D	A:83	(18.46, 11.43, 10.52)
15:75641496		S>P	A:84	(15.85, 12.26, 13.04)
15:75641503		Q>R	A:86	(10.68, 12.69, 15.02)
15:75641512		P>L	A:89	(1.95, 10.88, 18.81)
15:75641514		R>S	A:90	(2.87, 5.09, 22.14)
15:75641517		E>Q	A:91	(-1.13, 5.23, 18.46)
15:75641521		E>V	A:92	(0.88, 9.24, 15.16)
15:75641524		L>P	A:93	(5.12, 5.30, 15.95)
15:75641530		R>H	A:95	(6.49, 2.98, 7.98)
15:75641535	rs376577885	A>S	A:97	(11.42, 4.14, 14.07)
15:75641538		H>Y	A:98	(15.01, 2.41, 13.32)
15:75641545		R>L	A:100	(10.86, 2.90, 19.59)
15:75641553		T>A	A:103	(5.92, 8.89, 27.81)
15:75641559	rs368271056	P>S	A:105	(1.77, 7.11, 32.67)
15:75641565		G>R	A:107	(-0.01, 11.99, 30.31)
15:75641569	rs375734699	P>L	A:108	(-0.08, 12.89, 27.04)
15:75641571	COSM434314	R>W	A:109	(1.24, 7.60, 26.81)
15:75641572		R>Q	A:109	(1.24, 7.60, 26.81)
15:75641598		R>C	A:118	(18.78, 5.69, 3.02)
15:75641602		R>Q	A:119	(18.27, 1.27, 7.55)
15:75641610	rs369882175	R>C	A:122	(24.57, 5.54, 14.43)
15:75641619		L>V	A:125	(26.23, 1.62, 24.17)
15:75641620		L>P	A:125	(26.23, 1.62, 24.17)
15:75641623		G>E	A:126	(27.90, 5.67, 25.63)
15:75641636		Q>H	A:130	(34.13, 8.76, 17.45)
15:75641640		G>R	A:132	(39.72, 11.84, 17.30)
15:75641644		R>H	A:133	(35.19, 13.55, 15.75)
15:75641649		P>A	A:135	(37.54, 20.29, 19.20)
15:75641652	rs5745907	C>R	A:136	(33.15, 21.86, 18.65)
15:75641655		V>L	A:137	(33.54, 24.45, 15.58)
15:75641664		E>K	A:140	(35.01, 22.97, 22.00)
15:75641666		E>D	A:140	(35.01, 22.97, 22.00)
15:75644466	rs202072938	R>Q	A:150	(48.46, 21.81, 19.23)
15:75644474		A>S	A:153	(52.86, 19.47, 11.16)
15:75644475	rs367991477	A>E	A:153	(52.86, 19.47, 11.16)
15:75644477	rs186424955	D>H	A:154	(49.62, 16.58, 10.71)
15:75644487	COSM381197	F>S	A:157	(47.09, 20.65, 8.03)
15:75644489		D>H	A:158	(50.25, 18.27, 3.43)
15:75644490		D>V	A:158	(50.25, 18.27, 3.43)
15:75644504		E>K	A:163	(40.62, 17.65, 0.95)
15:75644523		R>K	A:169	(41.98, 14.07, 12.37)
15:75644537		I>V	A:174	(33.03, 21.51, 9.16)
15:75644538		I>T	A:174	(33.03, 21.51, 9.16)
15:75644553	COSM964975	R>Q	A:179	(34.03, 22.19, 1.86)
15:75644558		E>K	A:181	(29.41, 29.11, 2.21)
15:75644563	rs7183491	I>M	A:182	(34.03, 28.92, 5.22)
15:75644565		L>P	A:183	(36.61, 28.61, 1.39)
15:75644568		Y>S	A:184	(32.16, 33.02, -1.56)
15:75644570		R>W	A:185	(31.90, 34.24, 3.86)
15:75644571	rs139087139	R>Q	A:185	(31.90, 34.24, 3.86)
15:75644678	rs576317666	P>T	A:190	(39.71, 25.21, -3.08)
15:75644691		A>D	A:194	(46.41, 23.93, 4.06)
15:75644694	rs140143535	R>H	A:195	(50.91, 23.44, 6.24)
15:75644699	rs373195729	V>I	A:197	(45.81, 29.14, 4.34)
15:75644705	rs373409310	E>K	A:199	(51.93, 28.97, 7.51)
15:75644708		A>T	A:200	(50.00, 33.23, 9.45)
15:75644946		P>T	A:208	(47.57, 37.49, 26.91)
15:75644947	rs144861184	P>L	A:208	(47.57, 37.49, 26.91)
15:75644963		S>R	A:213	(41.48, 48.10, 21.12)
15:75644966		Q>H	A:214	(45.41, 46.03, 19.55)
15:75644970		I>V	A:216	(38.33, 46.44, 17.50)
15:75644971		I>T	A:216	(38.33, 46.44, 17.50)
15:75644972	rs570968686	I>M	A:216	(38.33, 46.44, 17.50)
15:75644974	rs534821044	R>K	A:217	(42.27, 49.95, 14.67)
15:75644991		P>T	A:223	(37.85, 37.67, 9.47)
15:75645012		H>Y	A:230	(32.44, 29.88, 15.78)
15:75645033		V>L	A:237	(22.36, 28.23, 14.94)
15:75646106	rs185157815	G>R	A:249	(10.41, 23.27, 7.39)
15:75646115	rs5745926	D>N	A:252	(13.26, 26.55, 8.44)
15:75646125		A>D	A:255	(16.13, 30.46, 4.93)
15:75646131		R>Q	A:257	(17.15, 27.67, -1.14)
15:75646139		L>V	A:260	(23.41, 29.33, 0.74)
15:75646142	rs202143068	R>C	A:261	(27.05, 34.13, 0.78)
15:75646143	rs534563246	R>H	A:261	(27.05, 34.13, 0.78)
15:75646146		C>S	A:262	(28.51, 29.01, -2.95)
15:75646160		G>S	A:267	(28.22, 30.12, -11.48)
15:75646182	rs148915219	R>Q	A:274	(41.26, 12.56, -1.16)
15:75646184		H>N	A:275	(37.61, 11.90, -0.19)
15:75646190		R>C	A:277	(33.29, 14.38, 0.09)
15:75646194	rs142213781	T>I	A:278	(31.21, 18.33, -4.65)
15:75646196		I>V	A:279	(34.16, 21.84, -3.67)
15:75646199		W>R	A:280	(29.55, 23.84, -5.63)
15:75646207		Q>H	A:282	(33.62, 32.51, -7.20)
15:75646594	rs146076543	D>H	A:284	(41.62, 29.77, -8.62)
15:75646604		P>L	A:287	(47.41, 24.66, -6.91)