Assessment of Structural Intolerance and Durability
General Structure Information 3vtw MAP1LC3B crystal structure of t7-tagged optineurin lir-fused human lc3b_2-119 2.52Å AUTH V.V.ROGOV,H.SUZUKI,E.FISKIN,P.WILD,A.KNISS,A.ROZENKNOP,AUTH 2 R.KATO,M.KAWASAKI,D.G.MCEWAN,F.LOHR,P.GUNTERT,I.DIKIC,AUTH 3 S.WAKATSUKI,V.DOTSCHTITL STRUCTURAL BASIS FOR PHOSPHORYLATION-TRIGGERED AUTOPHAGICTITL 2 CLEARANCE OF SALMONELLAREF BIOCHEM.J. V. 454 459 2013REFN ISSN 0264-6021PMID 23805866DOI 10.1042/BJ20121907 Variant Set Distributions Mapped Variants
General Structure Information 4gs9 EPAS1 crystal structure of the high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains in complex with an inactive benzoxadiazole antagonist 1.72Å AUTH J.L.ROGERS,L.BAYEH,T.H.SCHEUERMANN,J.LONGGOOD,J.KEY,AUTH 2 J.NAIDOO,L.MELITO,C.SHOKRI,D.E.FRANTZ,R.K.BRUICK,AUTH 3 K.H.GARDNER,J.B.MACMILLAN,U.K.TAMBARTITL DEVELOPMENT OF INHIBITORS OF THE PAS-B DOMAIN OF THE HIF-2TITL 2 ALPHA TRANSCRIPTION FACTORREF J.MED.CHEM. V. 56 1739 2013REFN ISSN 0022-2623PMID […]
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 1xcr C11orf54 crystal structure of longer splice variant of ptd012 from homo sapiens reveals a novel zinc-containing fold 1.7Å AUTH B.A.MANJASETTY,K.BUESSOW,M.FIEBER-ERDMANN,Y.ROSKE,J.GOBOM,AUTH 2 C.SCHEICH,F.GOETZ,F.H.NIESEN,U.HEINEMANNTITL CRYSTAL STRUCTURE OF HOMO SAPIENS PTD012 REVEALS ATITL 2 ZINC-CONTAINING HYDROLASE FOLDREF PROTEIN SCI. V. 15 914 2006REFN ISSN 0961-8368PMID 16522806DOI 10.1110/PS.052037006 Variant Set Distributions Mapped Variants
General Structure Information 2p31 GPX7 crystal structure of human glutathione peroxidase 7 2.0Å AUTH K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ldq MRI1 crystal structure of the mediator of rho dependent invasion 2.5Å AUTH P.D.TEMPLETON,E.S.LITMAN,S.I.METZNER,N.G.AHN,M.C.SOUSATITL STRUCTURE OF MEDIATOR OF RHOA-DEPENDENT INVASION (MRDI)TITL 2 EXPLAINS ITS DUAL FUNCTION AS A METABOLIC ENZYME AND ATITL 3 MEDIATOR OF CELL INVASION.REF BIOCHEMISTRY V. 52 5675 2013REFN ISSN 0006-2960PMID 23859498DOI 10.1021/BI400556E Variant Set Distributions Mapped Variants
General Structure Information 1wl4 ACAT2 human cytosolic acetoacetyl-coa thiolase complexed with coa 1.55Å AUTH P.KURSULA,H.SIKKILA,T.FUKAO,N.KONDO,R.K.WIERENGATITL HIGH RESOLUTION CRYSTAL STRUCTURES OF HUMAN CYTOSOLICTITL 2 THIOLASE (CT): A COMPARISON OF THE ACTIVE SITES OF HUMAN CT,TITL 3 BACTERIAL THIOLASE, AND BACTERIAL KAS IREF J.MOL.BIOL. V. 347 189 2005REFN ISSN 0022-2836PMID 15733928DOI 10.1016/J.JMB.2005.01.018 Variant Set Distributions Ripley’s K […]
General Structure Information 4ifp NLRP1 x-ray crystal structure of human nlrp1 card domain 1.99Å AUTH T.JIN,J.CURRY,P.SMITH,J.JIANG,T.S.XIAOTITL STRUCTURE OF THE NLRP1 CASPASE RECRUITMENT DOMAIN SUGGESTSTITL 2 POTENTIAL MECHANISMS FOR ITS ASSOCIATION WITH PROCASPASE-1.REF PROTEINS V. 81 1266 2013REFN ISSN 0887-3585PMID 23508996DOI 10.1002/PROT.24287 Variant Set Distributions Mapped Variants
General Structure Information 1ncu TTN titin module m5, n-terminally extended, nmr -1.0Å AUTH M.PFUHL,S.IMPROTA,A.S.POLITOUS,A.PASTORETITL WHEN A MODULE IS ALSO A DOMAIN: THE ROLE OF THE NTITL 2 TERMINUS IN THE STABILITY AND THE DYNAMICS OFTITL 3 IMMUNOGLOBULIN DOMAINS FROM TITIN.REF J.MOL.BIOL. V. 265 242 1997REFN ISSN 0022-2836PMID 9020985DOI 10.1006/JMBI.1996.0725 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1uen NRCAM solution structure of the third fibronectin iii domain of human kiaa0343 protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,F.HAYASHI,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD FIBRONECTIN IIITITL 2 DOMAIN OF HUMAN KIAA0343 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants