Assessment of Structural Intolerance and Durability
General Structure Information 4fc6 DECR2 studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr 2.1Å AUTH T.HUA,D.WU,W.DING,J.WANG,N.SHAW,Z.J.LIUTITL STUDIES OF HUMAN 2,4-DIENOYL COA REDUCTASE SHED NEW LIGHT ONTITL 2 PEROXISOMAL BETA-OXIDATION OF UNSATURATED FATTY ACIDSREF J.BIOL.CHEM. V. 287 28956 2012REFN ISSN 0021-9258PMID 22745130DOI 10.1074/JBC.M112.385351 Variant Set Distributions Ripley’s […]
General Structure Information 4gdk ATG5 crystal structure of human atg12~atg5 conjugate in complex with an n- terminal fragment of atg16l1 2.7Å AUTH C.OTOMO,Z.METLAGEL,G.TAKAESU,T.OTOMOTITL STRUCTURE OF THE HUMAN ATG12~ATG5 CONJUGATE REQUIRED FOR LC3TITL 2 LIPIDATION IN AUTOPHAGY.REF NAT.STRUCT.MOL.BIOL. V. 20 59 2013REFN ISSN 1545-9993PMID 23202584DOI 10.1038/NSMB.2431 Variant Set Distributions Mapped Variants
General Structure Information 2p39 FGF23 crystal structure of human fgf23 1.5Å AUTH R.GOETZ,A.BEENKEN,O.A.IBRAHIMI,J.KALININA,AUTH 2 S.K.OLSEN,A.V.ELISEENKOVA,C.XU,T.A.NEUBERT,F.ZHANG,AUTH 3 R.J.LINHARDT,X.YU,K.E.WHITE,T.INAGAKI,S.A.KLIEWER,AUTH 4 M.YAMAMOTO,H.KUROSU,Y.OGAWA,M.KURO-O,B.LANSKE,AUTH 5 M.S.RAZZAQUE,M.MOHAMMADITITL MOLECULAR INSIGHTS INTO THE KLOTHO-DEPENDENT,TITL 2 ENDOCRINE MODE OF ACTION OF FIBROBLAST GROWTHTITL 3 FACTOR 19 SUBFAMILY MEMBERS.REF MOL.CELL.BIOL. V. 27 3417 2007REFN ISSN 0270-7306PMID 17339340DOI 10.1128/MCB.02249-06 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4h5s CADM1 complex structure of necl-2 and crtam 1.7Å AUTH S.ZHANG,G.LU,J.QI,Y.LI,Z.ZHANG,B.ZHANG,Z.FAN,J.YAN,G.F.GAOTITL COMPETITION OF CELL ADHESION AND IMMUNE RECOGNITION:TITL 2 INSIGHTS INTO THE INTERACTION BETWEEN CRTAM AND NECTIN-LIKETITL 3 2REF STRUCTURE V. 21 2013REFN ISSN 0969-2126PMID 23871486DOI 10.1016/J.STR.2013.06.006 Variant Set Distributions Mapped Variants
General Structure Information 3qrf FOXP3 structure of a domain-swapped foxp3 dimer 2.8Å AUTH H.S.BANDUKWALA,Y.WU,M.FEUERER,Y.CHEN,B.BARBOZA,S.GHOSH,AUTH 2 J.C.STROUD,C.BENOIST,D.MATHIS,A.RAO,L.CHENTITL STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER ON DNA AND ITSTITL 2 FUNCTION IN REGULATORY T CELLS.REF IMMUNITY V. 34 479 2011REFN ISSN 1074-7613PMID 21458306DOI 10.1016/J.IMMUNI.2011.02.017 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2b6f SRXN1 solution structure of human sulfiredoxin (srx) -1.0Å AUTH D.-Y.LEE,S.J.PARK,W.JEONG,H.J.SUNG,T.OHO,X.WU,AUTH 2 S.G.RHEE,J.M.GRUSCHUSTITL MUTAGENESIS AND MODELING OF THE PEROXIREDOXINTITL 2 (PRX) COMPLEX WITH THE NMR STRUCTURE OF ATP-BOUNDTITL 3 HUMAN SULFIREDOXIN IMPLICATE ASPARTATE 187 OF PRXTITL 4 I AS THE CATALYTIC RESIDUE IN ATP HYDROLYSISREF BIOCHEMISTRY V. 45 15301 2006REFN ISSN 0006-2960PMID […]
General Structure Information 1q33 NUDT9 crystal structure of human adp-ribose pyrophosphatase nudt9 1.81Å AUTH B.W.SHEN,A.L.PERRAUD,A.SCHARENBERG,B.L.STODDARDTITL THE CRYSTAL STRUCTURE AND MUTATIONAL ANALYSIS OFTITL 2 HUMAN NUDT9REF J.MOL.BIOL. V. 332 385 2003REFN ISSN 0022-2836PMID 12948489DOI 10.1016/S0022-2836(03)00954-9 Variant Set Distributions Mapped Variants
General Structure Information 1u7t HSD17B10 crystal structure of abad/hsd10 with a bound inhibitor 2.0Å AUTH C.R.KISSINGER,P.A.REJTO,L.A.PELLETIER,J.A.THOMSON,AUTH 2 R.E.SHOWALTER,M.A.ABREO,C.S.AGREE,S.MARGOSIAK,AUTH 3 J.J.MENG,R.M.AUST,D.VANDERPOOL,B.LI,AUTH 4 A.TEMPCZYK-RUSSELL,J.E.VILLAFRANCATITL CRYSTAL STRUCTURE OF HUMAN ABAD/HSD10 WITH A BOUNDTITL 2 INHIBITOR: IMPLICATIONS FOR DESIGN OF ALZHEIMERSTITL 3 DISEASE THERAPEUTICSREF J.MOL.BIOL. V. 342 943 2004REFN ISSN 0022-2836PMID 15342248DOI 10.1016/J.JMB.2004.07.071 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3h8v UBA5 human ubiquitin-activating enzyme 5 in complex with atp 2.0Å AUTH J.P.BACIK,J.R.WALKER,M.ALI,A.D.SCHIMMER,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN UBIQUITIN-ACTIVATING ENZYME 5TITL 2 (UBA5) BOUND TO ATP: MECHANISTIC INSIGHTS INTO ATITL 3 MINIMALISTIC E1 ENZYME.REF J.BIOL.CHEM. V. 285 20273 2010REFN ISSN 0021-9258PMID 20368332DOI 10.1074/JBC.M110.102921 Variant Set Distributions Mapped Variants
General Structure Information 3rk6 PAIP1 crystal structure of the middle domain of human paip1 2.0Å AUTH J.LEI,J.R.MESTERS,A.BRUNN,R.HILGENFELDTITL CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMANTITL 2 POLY(A)-BINDING PROTEIN-INTERACTING PROTEIN 1.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 408 680 2011REFN ISSN 0006-291XPMID 21539810DOI 10.1016/J.BBRC.2011.04.088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants