Assessment of Structural Intolerance and Durability
General Structure Information 3pb9 QPCTL crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase in complex with 1-benzylimidazole 1.12Å AUTH K.F.HUANG,S.S.LIAW,W.L.HUANG,C.Y.CHIA,Y.C.LO,Y.L.CHEN,AUTH 2 A.H.J.WANGTITL STRUCTURES OF HUMAN GOLGI-RESIDENT GLUTAMINYL CYCLASE ANDTITL 2 ITS COMPLEXES WITH INHIBITORS REVEAL A LARGE LOOP MOVEMENTTITL 3 UPON INHIBITOR BINDINGREF J.BIOL.CHEM. V. 286 12439 2011REFN ISSN 0021-9258PMID 21288892DOI 10.1074/JBC.M110.208595 […]
General Structure Information 4l1d SCN3B voltage-gated sodium channel beta3 subunit ig domain 2.5Å AUTH S.NAMADURAI,D.BALASURIYA,R.RAJAPPA,M.WIEMHOFER,K.STOTT,AUTH 2 J.KLINGAUF,J.M.EDWARDSON,D.Y.CHIRGADZE,A.P.JACKSONTITL CRYSTAL STRUCTURE AND MOLECULAR IMAGING OF THE NAV CHANNELTITL 2 BETA 3 SUBUNIT INDICATES A TRIMERIC ASSEMBLY.REF J.BIOL.CHEM. V. 289 10797 2014REFN ISSN 0021-9258PMID 24567321DOI 10.1074/JBC.M113.527994 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ctz XPNPEP1 structure of human cytosolic x-prolyl aminopeptidase 1.6Å AUTH X.LI,Z.LOU,X.LI,W.ZHOU,M.MA,Y.CAO,Y.GENG,M.BARTLAM,AUTH 2 X.C.ZHANG,Z.RAOTITL STRUCTURE OF HUMAN CYTOSOLIC X-PROLYL AMINOPEPTIDASE: ATITL 2 DOUBLE MN(II)-DEPENDENT DIMERIC ENZYME WITH A NOVELTITL 3 THREE-DOMAIN SUBUNITREF J.BIOL.CHEM. V. 283 22858 2008REFN ISSN 0021-9258PMID 18515364DOI 10.1074/JBC.M710274200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3n2n ANTXR1 the crystal structure of tumor endothelial marker 8 (tem8) extracellular domain 1.8Å AUTH S.FU,X.TONG,C.CAI,Y.ZHAO,Y.WU,Y.LI,J.XU,X.C.ZHANG,L.XU,AUTH 2 W.CHEN,Z.RAOTITL THE STRUCTURE OF TUMOR ENDOTHELIAL MARKER 8 (TEM8)TITL 2 EXTRACELLULAR DOMAIN AND IMPLICATIONS FOR ITS RECEPTORTITL 3 FUNCTION FOR RECOGNIZING ANTHRAX TOXIN.REF PLOS ONE V. 5 E1120 2010REFN ESSN 1932-6203PMID 20585457DOI 10.1371/JOURNAL.PONE.0011203 Variant Set […]
General Structure Information 2ht9 GLRX2 the structure of dimeric human glutaredoxin 2 1.9Å AUTH C.JOHANSSON,K.L.KAVANAGH,O.GILEADI,U.OPPERMANNTITL REVERSIBLE SEQUESTRATION OF ACTIVE SITE CYSTEINES IN ATITL 2 2FE-2S-BRIDGED DIMER PROVIDES A MECHANISM FOR GLUTAREDOXIN 2TITL 3 REGULATION IN HUMAN MITOCHONDRIAREF J.BIOL.CHEM. V. 282 3077 2007REFN ISSN 0021-9258PMID 17121859DOI 10.1074/JBC.M608179200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3o4o IL1RAP crystal structure of an interleukin-1 receptor complex 3.3Å AUTH D.L.WANG,S.Y.ZHANG,L.LI,X.LIU,K.R.MEI,X.Q.WANGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND ACTIVATION OFTITL 2 IL-1BETA WITH ITS RECEPTORSREF NAT.IMMUNOL. V. 11 905 2010REFN ISSN 1529-2908PMID 20802483DOI 10.1038/NI.1925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y96 GEMIN7 crystal structure of the gemin6/gemin7 heterodimer from the human smn complex 2.0Å AUTH Y.MA,J.DOSTIE,G.DREYFUSS,G.D.VAN DUYNETITL THE GEMIN6-GEMIN7 HETERODIMER FROM THE SURVIVAL OFTITL 2 MOTOR NEURONS COMPLEX HAS AN SM PROTEIN-LIKETITL 3 STRUCTURE.REF STRUCTURE V. 13 883 2005REFN ISSN 0969-2126PMID 15939020DOI 10.1016/J.STR.2005.03.014 Variant Set Distributions Mapped Variants
General Structure Information 4dpz HRASLS2 crystal structure of human hrasls2 1.25Å AUTH M.GOLCZAK,P.D.KISER,A.E.SEARS,D.T.LODOWSKI,W.S.BLANER,AUTH 2 K.PALCZEWSKITITL STRUCTURAL BASIS FOR THE ACYLTRANSFERASE ACTIVITY OFTITL 2 LECITHIN:RETINOL ACYLTRANSFERASE-LIKE PROTEINS.REF J.BIOL.CHEM. V. 287 23790 2012REFN ISSN 0021-9258PMID 22605381DOI 10.1074/JBC.M112.361550 Variant Set Distributions Mapped Variants
General Structure Information 4joi OBFC1 crystal structure of the human telomeric stn1-ten1 complex 2.05Å AUTH C.BRYAN,C.RICE,M.HARKISHEIMER,D.C.SCHULTZ,E.SKORDALAKESTITL STRUCTURE OF THE HUMAN TELOMERIC STN1-TEN1 CAPPING COMPLEX.REF PLOS ONE V. 8 66756 2013REFN ESSN 1932-6203PMID 23826127DOI 10.1371/JOURNAL.PONE.0066756 Variant Set Distributions Mapped Variants
General Structure Information 4kgh BPIFA1 crystal structure of human splunc1 lacking the secretion signal sequence 2.81Å AUTH A.L.GARLAND,W.G.WALTON,R.D.COAKLEY,C.D.TAN,R.C.GILMORE,AUTH 2 C.A.HOBBS,A.TRIPATHY,L.A.CLUNES,S.BENCHARIT,M.J.STUTTS,AUTH 3 L.BETTS,M.R.REDINBO,R.TARRANTITL MOLECULAR BASIS FOR PH-DEPENDENT MUCOSAL DEHYDRATION INTITL 2 CYSTIC FIBROSIS AIRWAYS.REF PROC.NATL.ACAD.SCI.USA V. 110 15973 2013REFN ISSN 0027-8424PMID 24043776DOI 10.1073/PNAS.1311999110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]