Assessment of Structural Intolerance and Durability
General Structure Information 2d0j B3GAT2 crystal structure of human glcat-s apo form 2.0Å AUTH T.SHIBA,S.KAKUDA,M.ISHIGURO,I.MORITA,S.OKA,AUTH 2 T.KAWASAKI,S.WAKATSUKI,R.KATOTITL CRYSTAL STRUCTURE OF GLCAT-S, A HUMANTITL 2 GLUCURONYLTRANSFERASE, INVOLVED IN THETITL 3 BIOSYNTHESIS OF THE HNK-1 CARBOHYDRATE EPITOPEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1jlj GPHN 1.6 angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin 1.6Å AUTH G.SCHWARZ,N.SCHRADER,R.R.MENDEL,H.J.HECHT,AUTH 2 H.SCHINDELINTITL CRYSTAL STRUCTURES OF HUMAN GEPHYRIN AND PLANTTITL 2 CNX1 G DOMAINS: COMPARATIVE ANALYSIS ANDTITL 3 FUNCTIONAL IMPLICATIONS.REF J.MOL.BIOL. V. 312 405 2001REFN ISSN 0022-2836PMID 11554796DOI 10.1006/JMBI.2001.4952 Variant Set Distributions Ripley’s […]
General Structure Information 1uem ROBO2 solution structure of the first fibronectin type iii domain of human kiaa1568 protein -1.0Å AUTH H.LI,T.KIGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN KIAA1568 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2f0x ACOT13 crystal structure and function of human thioesterase superfamily member 2(them2) 2.3Å AUTH Z.CHENG,F.SONG,X.SHAN,Z.WEI,Y.WANG,AUTH 2 D.DUNAWAY-MARIANO,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN THIOESTERASETITL 2 SUPERFAMILY MEMBER 2REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 349 172 2006REFN ISSN 0006-291XPMID 16934754DOI 10.1016/J.BBRC.2006.08.025 Variant Set Distributions Mapped Variants
General Structure Information 3ua9 TNKS2 crystal structure of human tankyrase 2 in complex with a selective inhibitor 2.15Å AUTH M.NARWAL,H.VENKANNAGARI,L.LEHTIOTITL STRUCTURAL BASIS OF SELECTIVE INHIBITION OF HUMANTITL 2 TANKYRASES.REF J.MED.CHEM. V. 55 1360 2012REFN ISSN 0022-2623PMID 22233320DOI 10.1021/JM201510P Variant Set Distributions Mapped Variants
General Structure Information 4day RMI1 crystal structure of the rmi core complex with mm2 peptide from fancm 3.3Å AUTH K.A.HOADLEY,Y.XUE,C.LING,M.TAKATA,W.WANG,J.L.KECKTITL DEFINING THE MOLECULAR INTERFACE THAT CONNECTS THE FANCONITITL 2 ANEMIA PROTEIN FANCM TO THE BLOOM SYNDROME DISSOLVASOME.REF PROC.NATL.ACAD.SCI.USA V. 109 4437 2012REFN ISSN 0027-8424PMID 22392978DOI 10.1073/PNAS.1117279109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1z4k NT5M structure of the d41n variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 3- monophosphate 1.75Å AUTH K.WALLDEN,B.RUZZENENTE,A.RINALDO-MATTHIS,V.BIANCHI,AUTH 2 P.NORDLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY OF THETITL 2 HUMAN MITOCHONDRIAL DEOXYRIBONUCLEOTIDASEREF STRUCTURE V. 13 1081 2005REFN ISSN 0969-2126PMID 16004879DOI 10.1016/J.STR.2005.04.023 Variant Set Distributions Mapped Variants
General Structure Information 3f1r FGF20 crystal structure of fgf20 dimer 2.5Å AUTH J.KALININA,S.A.BYRON,H.P.MAKARENKOVA,S.K.OLSEN,AUTH 2 A.V.ELISEENKOVA,W.J.LAROCHELLE,M.DHANABAL,S.BLAIS,AUTH 3 D.M.ORNITZ,L.A.DAY,T.A.NEUBERT,P.M.POLLOCK,AUTH 4 M.MOHAMMADITITL HOMODIMERIZATION CONTROLS THE FIBROBLAST GROWTHTITL 2 FACTOR 9 SUBFAMILYS RECEPTOR BINDING AND HEPARANTITL 3 SULFATE-DEPENDENT DIFFUSION IN THE EXTRACELLULARTITL 4 MATRIXREF MOL.CELL.BIOL. V. 29 4663 2009REFN ISSN 0270-7306PMID 19564416DOI 10.1128/MCB.01780-08 Variant Set Distributions Mapped Variants
General Structure Information 3o65 ATXN3L crystal structure of a josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity 2.7Å AUTH S.D.WEEKS,K.C.GRASTY,L.HERNANDEZ-CUEBAS,P.J.LOLLTITL CRYSTAL STRUCTURE OF A JOSEPHIN-UBIQUITIN COMPLEX:TITL 2 EVOLUTIONARY RESTRAINTS ON ATAXIN-3 DEUBIQUITINATINGTITL 3 ACTIVITY.REF J.BIOL.CHEM. V. 286 4555 2011REFN ISSN 0021-9258PMID 21118805DOI 10.1074/JBC.M110.177360 Variant Set Distributions Mapped Variants
General Structure Information 2ebm RWDD1 solution structure of the rwd domain of human rwd domain containing protein 1 -1.0Å AUTH M.YONEYAMA,T.TOMIZAWA,S.KOSHIBA,S.WATABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RWD DOMAIN OF HUMAN RWDTITL 2 DOMAIN CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants