General Structure Information
| PDB ID | 2b6f |
| HGNC Gene Label(s) | SRXN1 |
| Structure Name | solution structure of human sulfiredoxin (srx) |
| Resolution | -1.0Å |
| Reference | AUTH D.-Y.LEE,S.J.PARK,W.JEONG,H.J.SUNG,T.OHO,X.WU,AUTH 2 S.G.RHEE,J.M.GRUSCHUSTITL MUTAGENESIS AND MODELING OF THE PEROXIREDOXINTITL 2 (PRX) COMPLEX WITH THE NMR STRUCTURE OF ATP-BOUNDTITL 3 HUMAN SULFIREDOXIN IMPLICATE ASPARTATE 187 OF PRXTITL 4 I AS THE CATALYTIC RESIDUE IN ATP HYDROLYSISREF BIOCHEMISTRY V. 45 15301 2006REFN ISSN 0006-2960PMID 17176052DOI 10.1021/BI061824H |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 121 |
| Number Of SNVs | 28 |
| Number Of Permutations | 3524 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.172 |
| p-value | 0.004 |
COSMIC
| Number Of Residues | 121 |
| Number Of SNVs | 3 |
| Number Of Permutations | 67 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.497 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.381 |
| p-value | 0.779 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
