General Structure Information
| PDB ID | 4gs9 |
| HGNC Gene Label(s) | EPAS1 |
| Structure Name | crystal structure of the high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains in complex with an inactive benzoxadiazole antagonist |
| Resolution | 1.72Å |
| Reference | AUTH J.L.ROGERS,L.BAYEH,T.H.SCHEUERMANN,J.LONGGOOD,J.KEY,AUTH 2 J.NAIDOO,L.MELITO,C.SHOKRI,D.E.FRANTZ,R.K.BRUICK,AUTH 3 K.H.GARDNER,J.B.MACMILLAN,U.K.TAMBARTITL DEVELOPMENT OF INHIBITORS OF THE PAS-B DOMAIN OF THE HIF-2TITL 2 ALPHA TRANSCRIPTION FACTORREF J.MED.CHEM. V. 56 1739 2013REFN ISSN 0022-2623PMID 23363003DOI 10.1021/JM301847Z |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 104 |
| Number Of SNVs | 28 |
| Number Of Permutations | 4744 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.175 |
| p-value | 0.828 |
COSMIC
| Number Of Residues | 104 |
| Number Of SNVs | 4 |
| Number Of Permutations | 222 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.167 |
| p-value | 0.149 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.156 |
| p-value | 0.136 |