Assessment of Structural Intolerance and Durability
General Structure Information 1il8 IL8 three-dimensional structure of interleukin 8 in solution -1.0Å AUTH G.M.CLORE,E.APPELLA,M.YAMADA,K.MATSUSHIMA,AUTH 2 A.M.GRONENBORNTITL THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 INTITL 2 SOLUTION.REF BIOCHEMISTRY V. 29 1689 1990REFN ISSN 0006-2960PMID 2184886DOI 10.1021/BI00459A004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1n26 IL6R crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain 2.4Å AUTH J.N.VARGHESE,R.L.MORITZ,M.-Z.LOU,A.VAN DONKELAAR,H.JI,AUTH 2 N.IVANCIC,K.M.BRANSON,N.E.HALL,R.J.SIMPSONTITL STRUCTURE OF THE EXTRACELLULAR DOMAINS OF THE HUMANTITL 2 INTERLEUKIN-6 RECEPTOR ALPHA-CHAIN.REF PROC.NATL.ACAD.SCI.USA V. 99 15959 2002REFN ISSN 0027-8424PMID 12461182DOI 10.1073/PNAS.232432399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1jiq GPI crystal structure of human autocrine motility factor 1.9Å AUTH N.TANAKA,A.HAGA,H.UEMURA,H.AKIYAMA,T.FUNASAKA,AUTH 2 H.NAGASE,A.RAZ,K.T.NAKAMURATITL INHIBITION MECHANISM OF CYTOKINE ACTIVITY OF HUMANTITL 2 AUTOCRINE MOTILITY FACTOR EXAMINED BY CRYSTALTITL 3 STRUCTURE ANALYSES AND SITE-DIRECTED MUTAGENESISTITL 4 STUDIES.REF J.MOL.BIOL. V. 318 985 2002REFN ISSN 0022-2836PMID 12054796DOI 10.1016/S0022-2836(02)00186-9 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1kf9 GHR phage display derived variant of human growth hormone complexed with two copies of the extracellular domain of its receptor 2.6Å AUTH C.A.SCHIFFER,M.ULTSCH,S.WALSH,W.SOMERS,A.M.DE VOS,AUTH 2 A.A.KOSSIAKOFFTITL STRUCTURE OF A PHAGE DISPLAY DERIVED VARIANT OFTITL 2 HUMAN GROWTH HORMONE COMPLEXED TO TWO COPIES OFTITL 3 THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR: EVIDENCETITL […]
General Structure Information 3it8 TNF crystal structure of tnf alpha complexed with a poxvirus mhc-related tnf binding protein 2.8Å AUTH Z.YANG,A.P.WEST JR.,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF TNFA COMPLEXED WITH A POXVIRUSTITL 2 MHC-RELATED TNF BINDING PROTEINREF NAT.STRUCT.MOL.BIOL.REFN ESSN 1545-9985DOI 10.1038/NSMB.1683 Variant Set Distributions Mapped Variants
General Structure Information 1au1 IFNB1 human interferon-beta crystal structure 2.2Å AUTH M.KARPUSAS,M.NOLTE,C.B.BENTON,W.MEIER,W.N.LIPSCOMB,AUTH 2 S.GOELZTITL THE CRYSTAL STRUCTURE OF HUMAN INTERFERON BETA ATTITL 2 2.2-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 94 11813 1997REFN ISSN 0027-8424PMID 9342320DOI 10.1073/PNAS.94.22.11813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i1b IL1B crystallographic refinement of interleukin-1 beta at 2.0 angstroms resolution 2.0Å AUTH J.P.PRIESTLE,H.P.SCHAR,M.G.GRUTTERTITL CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN 1 BETATITL 2 AT 2.0 A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 86 9667 1989REFN ISSN 0027-8424PMID 2602367DOI 10.1073/PNAS.86.24.9667 Variant Set Distributions Mapped Variants
General Structure Information 1owa SPTA1 solution structural studies on human erythrocyte alpha spectrin n terminal tetramerization domain -1.0Å AUTH S.PARK,M.S.CAFFREY,M.E.JOHNSON,L.W.FUNGTITL SOLUTION STRUCTURAL STUDIES ON HUMAN ERYTHROCYTETITL 2 ALPHA-SPECTRIN TETRAMERIZATION SITE.REF J.BIOL.CHEM. V. 278 21837 2003REFN ISSN 0021-9258PMID 12672815DOI 10.1074/JBC.M300617200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ila IL1A structure of interleukin 1alpha at 2.7-angstroms resolution 2.3Å AUTH B.J.GRAVES,M.H.HATADA,W.A.HENDRICKSON,J.K.MILLER,AUTH 2 V.S.MADISON,Y.SATOWTITL STRUCTURE OF INTERLEUKIN 1 ALPHA AT 2.7-ATITL 2 RESOLUTION.REF BIOCHEMISTRY V. 29 2679 1990REFN ISSN 0006-2960PMID 2346741DOI 10.1021/BI00463A009 Variant Set Distributions Mapped Variants
General Structure Information 1alu IL6 human interleukin-6 1.9Å AUTH W.SOMERS,M.STAHL,J.S.SEEHRATITL 1.9 A CRYSTAL STRUCTURE OF INTERLEUKIN 6: IMPLICATIONS FOR ATITL 2 NOVEL MODE OF RECEPTOR DIMERIZATION AND SIGNALING.REF EMBO J. V. 16 989 1997REFN ISSN 0261-4189PMID 9118960DOI 10.1093/EMBOJ/16.5.989 Variant Set Distributions Mapped Variants