Assessment of Structural Intolerance and Durability
General Structure Information 1uc6 CNTFR solution structure of the carboxyl terminal domain of the ciliary neurotrophic factor receptor -1.0Å AUTH D.MAN,W.HE,K.H.SZE,K.GONG,D.K.SMITH,G.ZHU,N.Y.IPTITL SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF THETITL 2 CILIARY NEUROTROPHIC FACTOR (CNTF) RECEPTOR ANDTITL 3 LIGAND FREE ASSOCIATIONS AMONG COMPONENTS OF THETITL 4 CNTF RECEPTOR COMPLEXREF J.BIOL.CHEM. V. 278 23285 2003REFN ISSN 0021-9258PMID […]
General Structure Information 1pvh LIF crystal structure of leukemia inhibitory factor in complex with gp130 2.5Å AUTH M.J.BOULANGER,A.J.BANKOVICH,T.KORTEMME,D.BAKER,AUTH 2 K.C.GARCIATITL CONVERGENT MECHANISMS FOR RECOGNITION OF DIVERGENTTITL 2 CYTOKINES BY THE SHARED SIGNALING RECEPTOR GP130.REF MOL.CELL V. 12 577 2003REFN ISSN 1097-2765PMID 14527405DOI 10.1016/S1097-2765(03)00365-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3cxe CSF2RA structure of the gm-csf receptor complex 3.3Å AUTH G.HANSEN,T.R.HERCUS,B.J.MCCLURE,F.C.STOMSKI,M.DOTTORE,AUTH 2 J.POWELL,H.RAMSHAW,J.M.WOODCOCK,Y.XU,M.GUTHRIDGE,AUTH 3 W.J.MCKINSTRY,A.F.LOPEZ,M.W.PARKERTITL THE STRUCTURE OF THE GM-CSF RECEPTOR COMPLEX REVEALS ATITL 2 DISTINCT MODE OF CYTOKINE RECEPTOR ACTIVATIONREF CELL(CAMBRIDGE,MASS.) V. 134 496 2008REFN ISSN 0092-8674PMID 18692472DOI 10.1016/J.CELL.2008.05.053 Variant Set Distributions Mapped Variants
General Structure Information 3di2 IL7R crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain 2.7Å AUTH C.A.MCELROY,J.A.DOHM,S.T.WALSHTITL STRUCTURAL AND BIOPHYSICAL STUDIES OF THE HUMANTITL 2 IL-7/IL-7RALPHA COMPLEX.REF STRUCTURE V. 17 54 2009REFN ISSN 0969-2126PMID 19141282DOI 10.1016/J.STR.2008.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3di2 IL7 crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain 2.7Å AUTH C.A.MCELROY,J.A.DOHM,S.T.WALSHTITL STRUCTURAL AND BIOPHYSICAL STUDIES OF THE HUMANTITL 2 IL-7/IL-7RALPHA COMPLEX.REF STRUCTURE V. 17 54 2009REFN ISSN 0969-2126PMID 19141282DOI 10.1016/J.STR.2008.10.019 Variant Set Distributions Mapped Variants
General Structure Information 3bk3 BMP2 crystal structure of the complex of bmp-2 and the first von willebrand domain type c of crossveinless-2 2.7Å AUTH J.-L.ZHANG,L.-Y.QIU,A.KOTZSCH,S.WEIDAUER,AUTH 2 L.PATTERSON,M.HAMMERSCHMIDT,W.SEBALD,T.D.MUELLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS HOW THE CHORDINTITL 2 FAMILY MEMBER CROSSVEINLESS 2 BLOCKS BMP-2TITL 3 RECEPTOR BINDINGREF DEV.CELL V. 14 739 2008REFN ISSN 1534-5807PMID 18477456DOI 10.1016/J.DEVCEL.2008.02.017 Variant Set […]
General Structure Information 1ilt IL1RN x-ray structure of interleukin-1 receptor antagonist at 2.0 angstroms resolution 2.0Å AUTH G.P.VIGERS,P.CAFFES,R.J.EVANS,R.C.THOMPSON,AUTH 2 S.P.EISENBERG,B.J.BRANDHUBERTITL X-RAY STRUCTURE OF INTERLEUKIN-1 RECEPTORTITL 2 ANTAGONIST AT 2.0-A RESOLUTION.REF J.BIOL.CHEM. V. 269 12874 1994REFN ISSN 0021-9258PMID 8175703 Variant Set Distributions Mapped Variants
General Structure Information 1ext TNFRSF1A extracellular domain of the 55kda tumor necrosis factor receptor. crystallized at ph3.7 in p 21 21 21. 1.85Å AUTH J.H.NAISMITH,T.Q.DEVINE,T.KOHNO,S.R.SPRANGTITL STRUCTURES OF THE EXTRACELLULAR DOMAIN OF THE TYPETITL 2 I TUMOR NECROSIS FACTOR RECEPTOR.REF STRUCTURE V. 4 1251 1996REFN ISSN 0969-2126PMID 8939750DOI 10.1016/S0969-2126(96)00134-7 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3alq TNFRSF1B crystal structure of tnf-tnfr2 complex 3.0Å AUTH Y.MUKAI,T.NAKAMURA,M.YOSHIKAWA,Y.YOSHIOKA,S.I.TSUNODA,AUTH 2 S.NAKAGAWA,Y.YAMAGATA,Y.TSUTSUMITITL SOLUTION OF THE STRUCTURE OF THE TNF-TNFR2 COMPLEXREF SCI.SIGNAL. V. 3 RA83 2010REFN ESSN 1937-9145PMID 21081755DOI 10.1126/SCISIGNAL.2000954 Variant Set Distributions Mapped Variants