Assessment of Structural Intolerance and Durability
General Structure Information 2b90 IL4 crystal structure of the interleukin-4 variant t13dr85a 2.1Å AUTH M.KRAICH,M.KLEIN,E.PATINO,H.HARRER,J.NICKEL,W.SEBALD,AUTH 2 T.D.MUELLERTITL A MODULAR INTERFACE OF IL-4 ALLOWS FOR SCALABLE AFFINITYTITL 2 WITHOUT AFFECTING SPECIFICITY FOR THE IL-4 RECEPTORREF BMC BIOL. V. 4 13 2006REFN ESSN 1741-7007PMID 16640778DOI 10.1186/1741-7007-4-13 Variant Set Distributions Mapped Variants
General Structure Information 2hdl CXCL14 solution structure of brak/cxcl14 -1.0Å AUTH F.C.PETERSON,J.A.THORPE,A.G.HARDER,B.F.VOLKMAN,AUTH 2 S.R.SCHWARZETITL STRUCTURAL DETERMINANTS INVOLVED IN THE REGULATIONTITL 2 OF CXCL14/BRAK EXPRESSION BY THE 26 S PROTEASOME.REF J.MOL.BIOL. V. 363 813 2006REFN ISSN 0022-2836PMID 16987528DOI 10.1016/J.JMB.2006.08.057 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rjk TNFSF15 crystal structure of human tl1a extracellular domain c95s mutant 2.3Å AUTH C.ZHAN,Q.YAN,Y.PATSKOVSKY,Z.LI,R.TORO,A.MEYER,AUTH 2 H.CHENG,M.BRENOWITZ,S.G.NATHENSON,S.C.ALMOTITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THETITL 2 HUMAN TL1A ECTODOMAIN.REF BIOCHEMISTRY V. 48 7636 2009REFN ISSN 0006-2960PMID 19522538DOI 10.1021/BI900031W Variant Set Distributions Mapped Variants
General Structure Information 3urf TNFSF11 human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3urf TNFRSF11B human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l4n CCL21 solution structure of the chemokine ccl21 -1.0Å AUTH M.LOVE,J.L.SANDBERG,J.J.ZIAREK,K.P.GERARDEN,R.R.RODE,AUTH 2 D.R.JENSEN,D.R.MCCASLIN,F.C.PETERSON,C.T.VELDKAMPTITL SOLUTION STRUCTURE OF CCL21 AND IDENTIFICATION OF A PUTATIVETITL 2 CCR7 BINDING SITE.REF BIOCHEMISTRY V. 51 733 2012REFN ISSN 0006-2960PMID 22221265DOI 10.1021/BI201601K Variant Set Distributions Mapped Variants
General Structure Information 1rjt CXCL11 nmr structure of cxc chemokine cxcl11/itac -1.0Å AUTH V.BOOTH,I.CLARK-LEWIS,B.D.SYKESTITL NMR STRUCTURE OF CXCR3 BINDING CHEMOKINE CXCL11TITL 2 (ITAC).REF PROTEIN SCI. V. 13 2022 2004REFN ISSN 0961-8368PMID 15273303DOI 10.1110/PS.04791404 Variant Set Distributions Mapped Variants
General Structure Information 4en0 TNFSF14 crystal structure of light 2.59Å AUTH W.LIU,C.ZHAN,H.CHENG,P.R.KUMAR,J.B.BONANNO,S.G.NATHENSON,AUTH 2 S.C.ALMOTITL MECHANISTIC BASIS FOR FUNCTIONAL PROMISCUITY IN THE TNF ANDTITL 2 TNF RECEPTOR SUPERFAMILIES: STRUCTURE OF THE LIGHT:DCR3TITL 3 ASSEMBLY.REF STRUCTURE V. 22 1252 2014REFN ISSN 0969-2126PMID 25087510DOI 10.1016/J.STR.2014.06.013 Variant Set Distributions Mapped Variants