General Structure Information
| PDB ID | 3di2 |
| HGNC Gene Label(s) | IL7R |
| Structure Name | crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain |
| Resolution | 2.7Å |
| Reference | AUTH C.A.MCELROY,J.A.DOHM,S.T.WALSHTITL STRUCTURAL AND BIOPHYSICAL STUDIES OF THE HUMANTITL 2 IL-7/IL-7RALPHA COMPLEX.REF STRUCTURE V. 17 54 2009REFN ISSN 0969-2126PMID 19141282DOI 10.1016/J.STR.2008.10.019 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 196 |
| Number Of SNVs | 69 |
| Number Of Permutations | 41435 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.046 |
| p-value | 0.543 |
ClinVar
| Number Of Residues | 196 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4978 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.0 |
| p-value | 0.855 |
COSMIC
| Number Of Residues | 196 |
| Number Of SNVs | 10 |
| Number Of Permutations | 3131 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.067 |
| p-value | 0.159 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | -0.046 |
| p-value | 0.812 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | -0.112 |
| p-value | 0.3 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
