Assessment of Structural Intolerance and Durability
General Structure Information 1plo TGFBR2 transforming growth factor-beta type ii receptor extracellular domain -1.0Å AUTH S.DEEP,K.P.WALKER III,Z.SHU,A.P.HINCKTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 TGF-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAINREF BIOCHEMISTRY V. 42 10126 2003REFN ISSN 0006-2960PMID 12939140DOI 10.1021/BI034366A Variant Set Distributions Mapped Variants
General Structure Information 1ax8 LEP human obesity protein, leptin 2.4Å AUTH F.ZHANG,M.B.BASINSKI,J.M.BEALS,S.L.BRIGGS,L.M.CHURGAY,AUTH 2 D.K.CLAWSON,R.D.DIMARCHI,T.C.FURMAN,J.E.HALE,H.M.HSIUNG,AUTH 3 B.E.SCHONER,D.P.SMITH,X.Y.ZHANG,J.P.WERY,R.W.SCHEVITZTITL CRYSTAL STRUCTURE OF THE OBESE PROTEIN LEPTIN-E100.REF NATURE V. 387 206 1997REFN ISSN 0028-0836PMID 9144295DOI 10.1038/387206A0 Variant Set Distributions Mapped Variants
General Structure Information 2×29 TNFSF9 crystal structure of human4-1bb ligand ectodomain 2.3Å AUTH E.Y.WON,K.CHA,J.S.BYUN,D.U.KIM,S.SHIN,B.AHN,Y.H.KIM,AUTH 2 A.J.RICE,T.WALZ,B.S.KWON,H.S.CHOTITL THE STRUCTURE OF THE TRIMER OF HUMAN 4-1BB LIGANDTITL 2 IS UNIQUE AMONG MEMBERS OF THE TUMOR NECROSISTITL 3 FACTOR SUPERFAMILY.REF J.BIOL.CHEM. V. 285 9202 2010REFN ISSN 0021-9258PMID 20032458DOI 10.1074/JBC.M109.084442 Variant Set Distributions Mapped Variants
General Structure Information 1gh7 CSF2RB crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf 3.0Å AUTH P.D.CARR,S.E.GUSTIN,A.P.CHURCH,J.M.MURPHY,S.C.FORD,D.A.MANN,AUTH 2 D.M.WOLTRING,I.WALKER,D.L.OLLIS,I.G.YOUNGTITL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE COMMONTITL 2 BETA SUBUNIT OF THE HUMAN GM-CSF, IL-3, AND IL-5 RECEPTORSTITL 3 REVEALS A NOVEL DIMER CONFIGURATION.REF CELL(CAMBRIDGE,MASS.) V. […]
General Structure Information 3qwr IL12B crystal structure of il-23 in complex with an adnectin 3.25Å AUTH V.RAMAMURTHY,S.R.KRYSTEK,A.BUSH,A.WEI,S.L.EMANUEL,AUTH 2 R.DAS GUPTA,A.JANJUA,L.CHENG,M.MURDOCK,B.ABRAMCZYK,D.COHEN,AUTH 3 Z.LIN,P.MORIN,J.H.DAVIS,M.DABRITZ,D.C.MCLAUGHLIN,K.A.RUSSO,AUTH 4 G.CHAO,M.C.WRIGHT,V.A.JENNY,L.J.ENGLE,E.FURFINE,S.SHERIFFTITL STRUCTURES OF ADNECTIN/PROTEIN COMPLEXES REVEAL AN EXPANDEDTITL 2 BINDING FOOTPRINT.REF STRUCTURE V. 20 259 2012REFN ISSN 0969-2126PMID 22325775DOI 10.1016/J.STR.2011.11.016 Variant Set Distributions Mapped Variants
General Structure Information 1cnt CNTF ciliary neurotrophic factor 2.4Å AUTH N.Q.MCDONALD,N.PANAYOTATOS,W.A.HENDRICKSONTITL CRYSTAL STRUCTURE OF DIMERIC HUMAN CILIARYTITL 2 NEUROTROPHIC FACTOR DETERMINED BY MAD PHASING.REF EMBO J. V. 14 2689 1995REFN ISSN 0261-4189PMID 7796798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r53 BMP6 crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6) 2.1Å AUTH S.SAREMBA,J.NICKEL,A.SEHER,A.KOTZSCH,W.SEBALD,AUTH 2 T.D.MUELLERTITL TYPE I RECEPTOR BINDING OF BONE MORPHOGENETICTITL 2 PROTEIN 6 IS DEPENDENT ON N-GLYCOSYLATION OF THETITL 3 LIGAND.REF FEBS J. V. 275 172 2007REFN ISSN 1742-464XPMID 18070108DOI 10.1111/J.1742-4658.2007.06187.X Variant Set Distributions Mapped Variants
General Structure Information 2hev TNFSF4 crystal structure of the complex between ox40l and ox40 2.41Å AUTH D.M.COMPAAN,S.G.HYMOWITZTITL THE CRYSTAL STRUCTURE OF THE COSTIMULATORY OX40-OX40LTITL 2 COMPLEX.REF STRUCTURE V. 14 1321 2006REFN ISSN 0969-2126PMID 16905106DOI 10.1016/J.STR.2006.06.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bpo IL4R crystal structure of the il13-il4r-il13ra ternary complex 3.0Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jye GRN human granulin a -1.0Å AUTH D.TOLKATCHEV,S.MALIK,A.VINOGRADOVA,P.WANG,Z.CHEN,AUTH 2 P.XU,H.P.BENNETT,A.BATEMAN,F.NITITL STRUCTURE DISSECTION OF HUMAN PROGRANULINTITL 2 IDENTIFIES WELL-FOLDED GRANULIN/EPITHELIN MODULESTITL 3 WITH UNIQUE FUNCTIONAL ACTIVITIES.REF PROTEIN SCI. V. 17 711 2008REFN ISSN 0961-8368PMID 18359860DOI 10.1110/PS.073295308 Variant Set Distributions Mapped Variants