1ILT.A | IL1RN

General Structure Information

PDB ID	1ilt
HGNC Gene Label(s)	IL1RN
Structure Name	x-ray structure of interleukin-1 receptor antagonist at 2.0 angstroms resolution
Resolution	2.0Å
Reference	AUTH G.P.VIGERS,P.CAFFES,R.J.EVANS,R.C.THOMPSON,AUTH 2 S.P.EISENBERG,B.J.BRANDHUBERTITL X-RAY STRUCTURE OF INTERLEUKIN-1 RECEPTORTITL 2 ANTAGONIST AT 2.0-A RESOLUTION.REF J.BIOL.CHEM. V. 269 12874 1994REFN ISSN 0021-9258PMID 8175703

Variant Set Distributions

ExAC Variants

Number Of Residues	143
Number Of SNVs	44
Number Of Permutations	12232
Optimal Distance Threshold	8.0
K Statistic	0.079
p-value	0.821

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:113885311		A>D	A:12	(1.93, 8.94, 36.18)
2:113887164		V>G	A:18	(-1.11, 24.82, 47.46)
2:113887205		A>S	A:32	(5.96, 26.73, 38.22)
2:113887208		G>R	A:33	(3.15, 28.97, 37.08)
2:113887223		P>T	A:38	(-3.83, 27.36, 24.92)
2:113887233		N>S	A:41	(-1.23, 21.95, 27.17)
2:113888636		V>I	A:49	(9.08, 4.96, 40.28)
2:113888642		I>F	A:51	(11.48, 2.72, 46.10)
2:113888643		I>T	A:51	(11.48, 2.72, 46.10)
2:113888648		P>T	A:53	(9.60, 2.18, 52.10)
2:113888652		H>R	A:54	(9.02, 5.90, 51.38)
2:113888657	rs374268790	L>V	A:56	(10.78, 7.45, 44.84)
2:113888673	rs367856609	H>R	A:61	(8.45, 13.41, 29.66)
2:113888675		G>R	A:62	(7.62, 9.77, 30.12)
2:113888683	rs138332136	K>N	A:64	(13.22, 10.47, 29.84)
2:113888684	rs372085115	M>V	A:65	(14.25, 13.23, 32.25)
2:113888688	rs201638660	C>F	A:66	(14.82, 12.96, 35.98)
2:113888714	COSM1481868 COSM1481867	E>K	A:75	(24.37, 25.23, 48.37)
2:113888721	rs371848779	R>T	A:77	(20.43, 22.98, 43.54)
2:113888728		Q>H	A:79	(18.59, 20.12, 37.91)
2:113890237		V>D	A:83	(18.58, 9.71, 32.01)
2:113890240	rs542605172	N>S	A:84	(15.91, 7.06, 31.80)
2:113890242		I>L	A:85	(13.90, 6.74, 35.02)
2:113890244		I>M	A:85	(13.90, 6.74, 35.02)
2:113890257		E>K	A:90	(17.81, 2.25, 44.41)
2:113890259		E>D	A:90	(17.81, 2.25, 44.41)
2:113890268		K>N	A:93	(24.94, 5.05, 45.26)
2:113890278	rs114004306	R>C	A:97	(21.10, 12.15, 43.53)
2:113890279	rs373101669 COSM288554 COSM288555	R>H	A:97	(21.10, 12.15, 43.53)
2:113890284	rs45507693	A>T	A:99	(15.92, 9.83, 45.18)
2:113890293	rs148520303	R>C	A:102	(7.74, 11.30, 50.18)
2:113890294	COSM1398902 COSM1398901	R>H	A:102	(7.74, 11.30, 50.18)
2:113890299		D>N	A:104	(2.08, 13.50, 53.39)
2:113890311		T>A	A:108	(-0.57, 17.40, 50.83)
2:113890315		T>I	A:109	(2.78, 15.82, 50.10)
2:113890332	rs565499594	A>T	A:115	(20.98, 12.82, 48.54)
2:113890341	rs143317628	G>S	A:118	(17.03, 18.68, 54.86)
2:113890345		W>L	A:119	(16.43, 20.05, 51.38)
2:113890360	rs374276440	A>V	A:124	(8.30, 30.49, 44.90)
2:113890363		M>T	A:125	(5.34, 32.62, 45.94)
2:113890380	rs56115412	V>I	A:131	(11.24, 24.96, 40.93)
2:113890383		S>G	A:132	(14.02, 24.55, 43.55)
2:113890384		S>N	A:132	(14.02, 24.55, 43.55)
2:113890390	rs550154177	T>I	A:134	(14.94, 24.82, 50.34)
2:113890399	rs146899714	P>L	A:137	(10.54, 24.14, 54.77)
2:113890408	COSM3894569 COSM3894567 COSM3894568	G>A	A:140	(6.78, 30.17, 54.89)
2:113890410	rs143208167	V>I	A:141	(9.27, 31.89, 52.58)
2:113890411		V>A	A:141	(9.27, 31.89, 52.58)
2:113890414		M>K	A:142	(8.84, 29.14, 49.88)
2:113890416	rs537765533 COSM3565492 COSM3565491	V>L	A:143	(6.08, 26.63, 49.10)
2:113890443	rs114929884	E>K	A:152	(-4.54, 6.23, 36.50)