Assessment of Structural Intolerance and Durability
General Structure Information 3i8e DDB1 crystal structure of ddb1 in complex with the h-box motif of wdr42a 3.4Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRAL HIJACKERSTITL 2 AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1 UBIQUITIN LIGASETITL 3 MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2e0a PDK4 crystal structure of human pyruvate dehydrogenase kinase 4 in complex with amppnp 1.86Å AUTH M.KUKIMOTO-NIINO,A.TOKMAKOV,T.TERADA,N.OHBAYASHI,T.FUJIMOTO,AUTH 2 S.GOMI,I.SHIROMIZU,M.KAWAMOTO,T.MATSUSUE,M.SHIROUZU,AUTH 3 S.YOKOYAMATITL INHIBITOR-BOUND STRUCTURES OF HUMAN PYRUVATE DEHYDROGENASETITL 2 KINASE 4.REF ACTA CRYSTALLOGR.,SECT.D V. 67 763 2011REFN ISSN 0907-4449PMID 21904029DOI 10.1107/S090744491102405X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3vfq PARP14 human parp14 (artd8, bal2) – macro domains 1 and 2 in complex with adenosine-5-diphosphoribose 2.8Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1jvg UAP1 crystal structure of human agx2 complexed with udpgalnac 2.3Å AUTH C.PENEFF,P.FERRARI,V.CHARRIER,Y.TABURET,C.MONNIER,AUTH 2 V.ZAMBONI,J.WINTER,M.HARNOIS,F.FASSY,Y.BOURNETITL CRYSTAL STRUCTURES OF TWO HUMAN PYROPHOSPHORYLASETITL 2 ISOFORMS IN COMPLEXES WITH UDPGLC(GAL)NAC: ROLE OFTITL 3 THE ALTERNATIVELY SPLICED INSERT IN THE ENZYMETITL 4 OLIGOMERIC ASSEMBLY AND ACTIVE SITE ARCHITECTURE.REF EMBO J. V. 20 6191 2001REFN ISSN 0261-4189PMID […]
General Structure Information 2ic1 CDO1 crystal structure of human cysteine dioxygenase in complex with substrate cysteine 2.7Å AUTH S.YE,X.WU,L.WEI,D.TANG,P.SUN,M.BARTLAM,Z.RAOTITL AN INSIGHT INTO THE MECHANISM OF HUMAN CYSTEINETITL 2 DIOXYGENASE: KEY ROLES OF THE THIOETHER-BONDEDTITL 3 TYROSINE-CYSTEINE COFACTOR.REF J.BIOL.CHEM. V. 282 3391 2007REFN ISSN 0021-9258PMID 17135237DOI 10.1074/JBC.M609337200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2d8s MARCH8 solution structure of the ring domain of the human cellular modulator of immune recognition protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 CELLULAR MODULATOR OF IMMUNE RECOGNITION PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2vcv GSTA3 glutathione transferase a3-3 in complex with glutathione and delta-4-androstene-3-17-dione 1.8Å AUTH K.TARS,B.OLIN,B.MANNERVIKTITL STRUCTURAL BASIS FOR FEATURING OF STEROID ISOMERASETITL 2 ACTIVITY IN ALPHA CLASS GLUTATHIONE TRANSFERASES.REF J.MOL.BIOL. V. 397 332 2010REFN ISSN 0022-2836PMID 20083122DOI 10.1016/J.JMB.2010.01.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y4i KSR2 ksr2-mek1 heterodimer 3.46Å AUTH D.F.BRENNAN,A.C.DAR,N.T.HERTZ,W.CHAO,A.L.BURLINGAME,AUTH 2 K.M.SHOKAT,D.BARFORDTITL A RAF-INDUCED ALLOSTERIC TRANSITION OF KSR STIMULATES KSRTITL 2 AND RAF PHOSPHORYLATION OF MEKREF NATURE V. 472 366 2011REFN ISSN 0028-0836PMID 21441910DOI 10.1038/NATURE09860 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2edv FRMPD1 solution structure of the pdz domain from human ferm and pdz domain containing 1 -1.0Å AUTH K.SEIMIYA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 FERM AND PDZ DOMAIN CONTAINING 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mkp DUSP6 crystal structure of pyst1 (mkp3) 2.35Å AUTH A.E.STEWART,S.DOWD,S.M.KEYSE,N.Q.MCDONALDTITL CRYSTAL STRUCTURE OF THE MAPK PHOSPHATASE PYST1TITL 2 CATALYTIC DOMAIN AND IMPLICATIONS FOR REGULATEDTITL 3 ACTIVATION.REF NAT.STRUCT.BIOL. V. 6 174 1999REFN ISSN 1072-8368PMID 10048930DOI 10.1038/5861 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants