General Structure Information
| PDB ID | 2ic1 |
| HGNC Gene Label(s) | CDO1 |
| Structure Name | crystal structure of human cysteine dioxygenase in complex with substrate cysteine |
| Resolution | 2.7Å |
| Reference | AUTH S.YE,X.WU,L.WEI,D.TANG,P.SUN,M.BARTLAM,Z.RAOTITL AN INSIGHT INTO THE MECHANISM OF HUMAN CYSTEINETITL 2 DIOXYGENASE: KEY ROLES OF THE THIOETHER-BONDEDTITL 3 TYROSINE-CYSTEINE COFACTOR.REF J.BIOL.CHEM. V. 282 3391 2007REFN ISSN 0021-9258PMID 17135237DOI 10.1074/JBC.M609337200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 185 |
| Number Of SNVs | 52 |
| Number Of Permutations | 15834 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.047 |
| p-value | 0.503 |
COSMIC
| Number Of Residues | 185 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2060 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.1 |
| p-value | 0.789 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.143 |
| p-value | 0.753 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
