Assessment of Structural Intolerance and Durability
General Structure Information 2v9k PUS10 crystal structure of human pus10, a novel pseudouridine synthase. 2.0Å AUTH C.J.MCCLEVERTY,M.HORNSBY,G.SPRAGGON,A.KREUSCHTITL CRYSTAL STRUCTURE OF HUMAN PUS10, A NOVEL PSEUDOURIDINETITL 2 SYNTHASE.REF J.MOL.BIOL. V. 373 1243 2007REFN ISSN 0022-2836PMID 17900615DOI 10.1016/J.JMB.2007.08.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ucr TIGIT crystal structure of the immunoreceptor tigit igv domain 2.63Å AUTH K.F.STENGEL,K.HARDEN-BOWLES,X.YU,L.ROUGE,J.YIN,AUTH 2 L.COMPS-AGRAR,C.WIESMANN,J.F.BAZAN,D.L.EATON,J.L.GROGANTITL STRUCTURE OF TIGIT IMMUNORECEPTOR BOUND TO POLIOVIRUSTITL 2 RECEPTOR REVEALS A CELL-CELL ADHESION AND SIGNALINGTITL 3 MECHANISM THAT REQUIRES CIS-TRANS RECEPTOR CLUSTERING.REF PROC.NATL.ACAD.SCI.USA V. 109 5399 2012REFN ISSN 0027-8424PMID 22421438DOI 10.1073/PNAS.1120606109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3e9l PRPF8 crystal structure of human prp8, residues 1755-2016 1.95Å AUTH V.PENA,A.ROZOV,P.FABRIZIO,R.LUHRMANN,M.C.WAHLTITL STRUCTURE AND FUNCTION OF AN RNASE H DOMAIN AT THE HEART OFTITL 2 THE SPLICEOSOME.REF EMBO J. V. 27 2929 2008REFN ISSN 0261-4189PMID 18843295DOI 10.1038/EMBOJ.2008.209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1de4 HFE hemochromatosis protein hfe complexed with transferrin receptor 2.8Å AUTH M.J.BENNETT,J.A.LEBRON,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF THE HEREDITARY HAEMOCHROMATOSIS PROTEINTITL 2 HFE COMPLEXED WITH TRANSFERRIN RECEPTOR.REF NATURE V. 403 46 2000REFN ISSN 0028-0836PMID 10638746DOI 10.1038/47417 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3v5q NTRK3 discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models 2.2Å AUTH P.ALBAUGH,Y.FAN,Y.MI,F.SUN,F ADRIAN,N.LI,Y.YIA,Y.SARKISOVA,AUTH 2 A.KREUSCH,T.HOOD,M.LU,G.LIU,S.HUANG,Z.LIU,J.LOREN,AUTH 3 T.TUNTLAND,D.S.KARANEWSKY,H.M.SEIDEL,V.MOLTENITITL DISCOVERY OF GNF-5837, A SELECTIVE TRK INHIBITOR WITHTITL 2 EFFICACY IN RODENT CANCER TUMOR MODELSREF ACS MED.CHEM.LETT. 2012REFN ISSN 1948-5875DOI 10.1021/ML200261D Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4hon KDM4D crystal structure of human jmjd2d/kdm4d in complex with an h3k9me3 peptide and 2-oxoglutarate 1.8Å AUTH S.KRISHNAN,R.C.TRIEVELTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF JMJD2D REVEALSTITL 2 MOLECULAR BASIS FOR SITE-SPECIFIC DEMETHYLATION AMONG JMJD2TITL 3 DEMETHYLASES.REF STRUCTURE V. 21 98 2013REFN ISSN 0969-2126PMID 23219879DOI 10.1016/J.STR.2012.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2y73 AOC3 the native structures of soluble human primary amine oxidase aoc3 2.6Å AUTH H.ELOVAARA,H.KIDRON,V.PARKASH,Y.NYMALM,E.BLIGT,P.OLLIKKA,AUTH 2 D.J.SMITH,M.PIHLAVISTO,M.SALMI,S.JALKANEN,T.A.SALMINENTITL IDENTIFICATION OF TWO IMIDAZOLE BINDING SITES AND KEYTITL 2 RESIDUES FOR SUBSTRATE SPECIFICITY IN HUMAN PRIMARY AMINETITL 3 OXIDASE AOC3.REF BIOCHEMISTRY V. 50 5507 2011REFN ISSN 0006-2960PMID 21585208DOI 10.1021/BI200117Z Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3she MAPKAPK3 novel atp-competitive mk2 inhibitors with potent biochemical and cell- based activity throughout the series 2.25Å AUTH A.OUBRIE,A.KAPTEIN,E.DE ZWART,N.HOOGENBOOM,R.GOORDEN,AUTH 2 B.VAN DE KAR,M.VAN HOEK,V.DE KIMPE,R.VAN DER HEIJDEN,AUTH 3 J.BORSBOOM,B.KAZEMIER,J.DE ROOS,M.SCHEFFERS,J.LOMMERSE,AUTH 4 C.SCHULTZ-FADEMRECHT,T.BARFTITL NOVEL ATP COMPETITIVE MK2 INHIBITORS WITH POTENT BIOCHEMICALTITL 2 AND CELL-BASED ACTIVITY THROUGHOUT THE SERIES.REF BIOORG.MED.CHEM.LETT. V. 22 613 […]
General Structure Information 3d8b FIGNL1 crystal structure of human fidgetin-like protein 1 in complex with adp 2.0Å AUTH T.KARLBERG,M.WISNIEWSKA,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,AUTH 5 M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,M.WELIN,AUTH 7 M.WIKSTROM,H.SCHULERTITL HUMAN FIDGETIN-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kgr LAIR1 crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1) 1.8Å AUTH T.H.C.BRONDIJK,T.DE RUITER,J.BALLERING,H.WIENK,R.J.LEBBINK,AUTH 2 H.VAN INGEN,R.BOELENS,R.W.FARNDALE,L.MEYAARD,E.G.HUIZINGATITL CRYSTAL STRUCTURE AND COLLAGEN-BINDING SITE OF IMMUNETITL 2 INHIBITORY RECEPTOR LAIR-1: UNEXPECTED IMPLICATIONS FORTITL 3 COLLAGEN BINDING BY PLATELET RECEPTOR GPVIREF BLOOD V. 115 1364 2010REFN ISSN 0006-4971PMID 20007810DOI 10.1182/BLOOD-2009-10-246322 Variant Set Distributions Ripley’s […]