General Structure Information
| PDB ID | 1mkp |
| HGNC Gene Label(s) | DUSP6 |
| Structure Name | crystal structure of pyst1 (mkp3) |
| Resolution | 2.35Å |
| Reference | AUTH A.E.STEWART,S.DOWD,S.M.KEYSE,N.Q.MCDONALDTITL CRYSTAL STRUCTURE OF THE MAPK PHOSPHATASE PYST1TITL 2 CATALYTIC DOMAIN AND IMPLICATIONS FOR REGULATEDTITL 3 ACTIVATION.REF NAT.STRUCT.BIOL. V. 6 174 1999REFN ISSN 1072-8368PMID 10048930DOI 10.1038/5861 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 143 |
| Number Of SNVs | 20 |
| Number Of Permutations | 5201 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.016 |
| p-value | 0.289 |
COSMIC
| Number Of Residues | 143 |
| Number Of SNVs | 5 |
| Number Of Permutations | 27 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.1 |
| p-value | 0.639 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 20 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.253 |
| p-value | 0.809 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
