General Structure Information
| PDB ID | 2e0a |
| HGNC Gene Label(s) | PDK4 |
| Structure Name | crystal structure of human pyruvate dehydrogenase kinase 4 in complex with amppnp |
| Resolution | 1.86Å |
| Reference | AUTH M.KUKIMOTO-NIINO,A.TOKMAKOV,T.TERADA,N.OHBAYASHI,T.FUJIMOTO,AUTH 2 S.GOMI,I.SHIROMIZU,M.KAWAMOTO,T.MATSUSUE,M.SHIROUZU,AUTH 3 S.YOKOYAMATITL INHIBITOR-BOUND STRUCTURES OF HUMAN PYRUVATE DEHYDROGENASETITL 2 KINASE 4.REF ACTA CRYSTALLOGR.,SECT.D V. 67 763 2011REFN ISSN 0907-4449PMID 21904029DOI 10.1107/S090744491102405X |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 358 |
| Number Of SNVs | 97 |
| Number Of Permutations | 42049 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.011 |
| p-value | 0.849 |
COSMIC
| Number Of Residues | 358 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1846 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.071 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 97 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.15 |
| p-value | 0.921 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
