General Structure Information
| PDB ID | 2y4i |
| HGNC Gene Label(s) | KSR2 |
| Structure Name | ksr2-mek1 heterodimer |
| Resolution | 3.46Å |
| Reference | AUTH D.F.BRENNAN,A.C.DAR,N.T.HERTZ,W.CHAO,A.L.BURLINGAME,AUTH 2 K.M.SHOKAT,D.BARFORDTITL A RAF-INDUCED ALLOSTERIC TRANSITION OF KSR STIMULATES KSRTITL 2 AND RAF PHOSPHORYLATION OF MEKREF NATURE V. 472 366 2011REFN ISSN 0028-0836PMID 21441910DOI 10.1038/NATURE09860 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 265 |
| Number Of SNVs | 49 |
| Number Of Permutations | 6584 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.145 |
| p-value | 0.149 |
COSMIC
| Number Of Residues | 265 |
| Number Of SNVs | 4 |
| Number Of Permutations | 466 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.667 |
| p-value | 0.296 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
