Assessment of Structural Intolerance and Durability
General Structure Information 3nbq UPP1 human uridine phosphorylase 1 (hupp1) with 5-fluorouracil 2.3Å AUTH T.P.ROOSILD,S.CASTRONOVOTITL ACTIVE SITE CONFORMATIONAL DYNAMICS IN HUMAN URIDINETITL 2 PHOSPHORYLASE 1.REF PLOS ONE V. 5 E1274 2010REFN ESSN 1932-6203PMID 20856879DOI 10.1371/JOURNAL.PONE.0012741 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qbv ITSN1 structure of designed orthogonal interaction between cdc42 and nucleotide exchange domains of intersectin 2.65Å AUTH G.T.KAPP,S.LIU,A.STEIN,D.T.WONG,A.REMENYI,B.J.YEH,AUTH 2 J.S.FRASER,J.TAUNTON,W.A.LIM,T.KORTEMMETITL CONTROL OF PROTEIN SIGNALING USING A COMPUTATIONALLYTITL 2 DESIGNED GTPASE/GEF ORTHOGONAL PAIR.REF PROC.NATL.ACAD.SCI.USA V. 109 5277 2012REFN ISSN 0027-8424PMID 22403064DOI 10.1073/PNAS.1114487109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4gn1 RAPH1 crystal structure of the ra and ph domains of lamellipodin 2.4Å AUTH Y.C.CHANG,H.ZHANG,M.L.BRENNAN,J.WUTITL CRYSTAL STRUCTURE OF LAMELLIPODIN IMPLICATES DIVERSETITL 2 FUNCTIONS IN ACTIN POLYMERIZATION AND RAS SIGNALING.REF PROTEIN CELL V. 4 211 2013REFN ISSN 1674-800XPMID 23483482DOI 10.1007/S13238-013-2082-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1wis SDK2 solution structure of the fifth fniii domain from human kiaa1514 protein -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH FNIII DOMAIN FROMTITL 2 HUMAN KIAA1514 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2w4o CAMK4 crystal structure of human camk4 in complex with 4-amino( sulfamoyl-phenylamino)-triazole-carbothioic acid (2,6- difluoro-phenyl)-amide) 2.17Å AUTH J.R.C.MUNIZ,P.RELLOS,O.GILEADI,O.FEDOROV,P.FILIPPAKOPOULOS,AUTH 2 E.SALAH,A.PIKE,C.PHILLIPS,F.NIESEN,L.SHRESTHA,AUTH 3 N.BURGESS-BROWN,A.BULLOCK,G.BERRIDGE,F.VON DELFT,AUTH 4 A.M.EDWARDS,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITHTITL 2 4-AMINO(SULFAMOYL-PHENYLAMINO)-TRIAZOLE- CARBOTHIOIC ACIDTITL 3 (2,6-DIFLUORO-PHENYL)-AMIDE)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4btm TTBK1 ttbk1 in complex with inhibitor 2.54Å AUTH Y.XUE,P.T.WAN,P.HILLERTZ,F.SCHWEIKART,Y.ZHAO,L.WISSLER,AUTH 2 N.DEKKERTITL X-RAY STRUCTURAL ANALYSIS OF TAU-TUBULIN KINASE 1 AND ITSTITL 2 INTERACTIONS WITH SMALL MOLECULAR INHIBITORS.REF CHEMMEDCHEM V. 8 1846 2013REFN ISSN 1860-7179PMID 24039150DOI 10.1002/CMDC.201300274 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2h8k SULT1C3 human sulfotranferase sult1c3 in complex with pap 3.2Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,AUTH 2 R.NAJMANOVICH,W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,AUTH 3 J.THORNTON,J.THONTON,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 A.N.PLOTNIKOV,M.VEDADI,C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMANTITL 2 CYTOSOLIC SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hvz SRSF7 solution structure of the rrm domain of sr rich factor 9g8 -1.0Å AUTH Y.HARGOUS,G.M.HAUTBERGUE,A.M.TINTARU,L.SKRISOVSKA,AUTH 2 A.P.GOLOVANOV,J.STEVENIN,L.Y.LIAN,S.A.WILSON,AUTH 3 F.H.ALLAINTITL MOLECULAR BASIS OF RNA RECOGNITION AND TAP BINDINGTITL 2 BY THE SR PROTEINS SRP20 AND 9G8.REF EMBO J. V. 25 5126 2006REFN ISSN 0261-4189PMID 17036044DOI 10.1038/SJ.EMBOJ.7601385 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3mqp BCL2A1 crystal structure of human bfl-1 in complex with noxa bh3 peptide, northeast structural genomics consortium target hr2930 2.24Å AUTH R.GUAN,R.XIAO,L.ZHAO,T.B.ACTON,C.GELINAS,G.T.MONTELIONETITL CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH NOXA BH3TITL 2 PEPTIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4hpm BCORL1 pcgf1 ub fold (rawul)/bcorl1 pufd complex 1.85Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]