Assessment of Structural Intolerance and Durability
General Structure Information 4a35 ENOSF1 crystal structure of human mitochondrial enolase superfamily member 1 (enosf1) 1.74Å AUTH J.R.C.MUNIZ,D.S.FROESE,T.KROJER,M.VOLLMAR,P.CANNING,AUTH 2 U.OPPERMANN,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 F.VON DELFT,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ENOLASETITL 2 SUPERFAMILY MEMBER 1 (ENOSF1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4f0d PARP16 human artd15/parp16 in complex with 3-aminobenzamide 2.7Å AUTH T.KARLBERG,A.G.THORSELL,A.KALLAS,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSE TRANSFERASETITL 2 ARTD15/PARP16 REVEALS A NOVEL PUTATIVE REGULATORY DOMAIN.REF J.BIOL.CHEM. V. 287 24077 2012REFN ISSN 0021-9258PMID 22661712DOI 10.1074/JBC.M112.379289 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ii7 KLHL7 crystal structure of the kelch domain of human klhl7 1.63Å AUTH P.CANNING,C.D.COOPER,T.KROJER,J.W.MURRAY,A.C.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,AUTH 3 V.AYINAMPUDI,B.D.MARSDEN,O.GILEADI,S.KNAPP,F.VON DELFT,AUTH 4 A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 PROTEIN ASSEMBLY WITH THETITL 2 BTB-KELCH FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4gll UXS1 crystal structure of human udp-xylose synthase. 2.5Å AUTH S.J.POLIZZI,R.M.WALSH,W.B.PEEPLES,J.M.LIM,L.WELLS,Z.A.WOODTITL HUMAN UDP-ALPHA-D-XYLOSE SYNTHASE AND ESCHERICHIA COLI ARNATITL 2 CONSERVE A CONFORMATIONAL SHUNT THAT CONTROLS WHETHER XYLOSETITL 3 OR 4-KETO-XYLOSE IS PRODUCED.REF BIOCHEMISTRY V. 51 8844 2012REFN ISSN 0006-2960PMID 23072385DOI 10.1021/BI301135B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3rq4 SUV420H2 crystal structure of suppressor of variegation 4-20 homolog 2 1.8Å AUTH H.WU,A.SIARHEYEVA,H.ZENG,R.LAM,A.DONG,X.H.WU,Y.LI,AUTH 2 M.SCHAPIRA,M.VEDADI,J.MINTITL CRYSTAL STRUCTURES OF THE HUMAN HISTONE H4K20TITL 2 METHYLTRANSFERASES SUV420H1 AND SUV420H2.REF FEBS LETT. V. 587 3859 2013REFN ISSN 0014-5793PMID 24396869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dh1 ADAT2 crystal structure of human trna-specific adenosine-34 deaminase subunit adat2 2.8Å AUTH M.WELIN,L.TRESAUGUES,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,S.VAN DER BERG,AUTH 6 M.WISNIEWSKA,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN TRNA-SPECIFIC ADENOSINE-34TITL 2 DEAMINASE SUBUNIT ADAT2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3og4 IFNLR1 the crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group p21212 2.16Å AUTH Z.J.MIKNIS,E.MAGRACHEVA,W.LI,A.ZDANOV,S.V.KOTENKO,A.WLODAWERTITL CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN INTERFERON-LAMBDA1TITL 2 WITH ITS HIGH AFFINITY RECEPTOR INTERFERON-LAMBDAR1.REF J.MOL.BIOL. V. 404 650 2010REFN ISSN 0022-2836PMID 20934432DOI 10.1016/J.JMB.2010.09.068 Variant Set Distributions Ripley’s K […]
General Structure Information 4nn2 PHF6 protein crystal structure of human borjeson-forssman-lehmann syndrome associated protein phf6 1.47Å AUTH Z.LIU,F.LI,J.ZHANG,Y.MEI,J.WU,Y.SHITITL CRYSTAL STRUCTURE OF THE SECOND EXTENDED PHD DOMAIN OF HUMANTITL 2 PHF6 PROTEINREF J.BIOL.CHEM. 2014REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2x4f MYLK4 the crystal structure of the human myosin light chain kinase loc340156. 2.67Å AUTH J.R.C.MUNIZ,P.MAHAJAN,P.RELLOS,O.FEDOROV,B.SHRESTHA,J.WANG,AUTH 2 J.M.ELKINS,N.DAGA,R.COCKING,A.CHAIKUAD,T.KROJER,E.UGOCHUKWU,AUTH 3 W.YUE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 4 C.BOUNTRA,O.GILEADI,S.KNAPPTITL THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAINTITL 2 KINASE LOC340156REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3bd9 HS3ST5 human 3-o-sulfotransferase isoform 5 with bound pap 2.3Å AUTH D.XU,A.F.MOON,D.SONG,L.C.PEDERSEN,J.LIUTITL ENGINEERING SULFOTRANSFERASES TO MODIFY HEPARANTITL 2 SULFATE.REF NAT.CHEM.BIOL. V. 4 200 2008REFN ISSN 1552-4450PMID 18223645DOI 10.1038/NCHEMBIO.66 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants