Assessment of Structural Intolerance and Durability
General Structure Information 2fv2 RQCD1 crystal structure analysis of human rcd-1 conserved region 2.2Å AUTH R.G.GARCES,W.GILLON,E.F.PAITITL ATOMIC MODEL OF HUMAN RCD-1 REVEALS ANTITL 2 ARMADILLO-LIKE-REPEAT PROTEIN WITH IN VITROTITL 3 NUCLEIC ACID BINDING PROPERTIES.REF PROTEIN SCI. V. 16 176 2007REFN ISSN 0961-8368PMID 17189474DOI 10.1110/PS.062600507 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4n4f CREBBP crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac). 1.83Å AUTH A.N.PLOTNIKOV,S.YANG,T.J.ZHOU,E.RUSINOVA,A.FRASCA,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO ACETYLATED-HISTONE H4 RECOGNITIONTITL 2 BY THE BROMODOMAIN-PHD FINGER MODULE OF HUMANTITL 3 TRANSCRIPTIONAL COACTIVATOR CBP.REF STRUCTURE V. 22 353 2014REFN ISSN 0969-2126PMID 24361270DOI 10.1016/J.STR.2013.10.021 […]
General Structure Information 4fr4 STK32A crystal structure of human serine/threonine-protein kinase 32a (yank1) 2.29Å AUTH A.CHAIKUAD,J.M.ELKINS,T.KROJER,P.MAHAJAN,S.GOUBIN,M.SZKLARZ,AUTH 2 A.TUMBER,J.WANG,P.SAVITSKY,B.SHRESTHA,N.DAGA,S.PICAUD,AUTH 3 O.FEDOROV,C.K.ALLERSTON,S.V.A.LATWIEL,M.VOLLMAR,P.CANNING,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,S.KNAPP,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASETITL 2 32A (YANK1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hbw FGF13 crystal structure of human fibroblast growth factor homologous factor 2a (fhf2a), also referred to as fibroblast growth factor 13a (fgf13a) 1.9Å AUTH R.GOETZ,K.DOVER,F.LAEZZA,N.SHTRAIZENT,X.HUANG,AUTH 2 D.TCHETCHIK,A.V.ELISEENKOVA,C.F.XU,T.A.NEUBERT,AUTH 3 D.M.ORNITZ,M.GOLDFARB,M.MOHAMMADITITL CRYSTAL STRUCTURE OF A FIBROBLAST GROWTH FACTORTITL 2 HOMOLOGOUS FACTOR (FHF) DEFINES A CONSERVED SURFACETITL 3 ON FHFS FOR BINDING AND MODULATION OF […]
General Structure Information 4a0d PARG structure of unliganded human parg catalytic domain 1.75Å AUTH J.A.TUCKER,N.BENNETT,C.BRASSINGTON,S.T.DURANT,G.HASSALL,AUTH 2 G.HOLDGATE,M.MCALISTER,J.W.M.NISSINK,C.TRUMAN,M.WATSONTITL STRUCTURES OF THE HUMAN POLY (ADP-RIBOSE) GLYCOHYDROLASETITL 2 CATALYTIC DOMAIN CONFIRM CATALYTIC MECHANISM AND EXPLAINTITL 3 INHIBITION BY ADP-HPD DERIVATIVES.REF PLOS ONE V. 7 50889 2012REFN ISSN 1932-6203PMID 23251397DOI 10.1371/JOURNAL.PONE.0050889 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1uit DLG5 solution structure of rsgi ruh-006, the third pdz domain of hdlg5 (kiaa0583) protein [homo sapiens] -1.0Å AUTH T.ABE,H.HIROTA,N.KOBAYASHI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-006, THE THIRD PDZTITL 2 DOMAIN OF HDLG5 (KIAA0583) PROTEIN [HOMO SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2wm1 ACMSD the crystal structure of human alpha-amino-beta- carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between nad synthesis and glycolysis 2.01Å AUTH S.GARAVAGLIA,S.PEROZZI,L.GALEAZZI,N.RAFFAELLI,AUTH 2 M.RIZZITITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA-AMINO-BETA-TITL 2 CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASETITL 3 IN COMPLEX WITH 1,3-DIHYDROXYACETONEPHOSPHATETITL 4 SUGGESTS A REGULATORY LINK BETWEEN NAD SYNTHESISTITL 5 […]
General Structure Information 3qxy SETD6 human setd6 in complex with rela lys310 2.09Å AUTH Y.CHANG,D.LEVY,J.R.HORTON,J.PENG,X.ZHANG,O.GOZANI,X.CHENGTITL STRUCTURAL BASIS OF SETD6-MEDIATED REGULATION OF THE NF-KBTITL 2 NETWORK VIA METHYL-LYSINE SIGNALING.REF NUCLEIC ACIDS RES. V. 39 6380 2011REFN ISSN 0305-1048PMID 21515635DOI 10.1093/NAR/GKR256 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wek ZADH2 crystal structure of the human mgc45594 gene product in complex with diclofenac 1.9Å AUTH N.SHAFQAT,W.W.YUE,F.NIESEN,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT INTITL 2 COMPLEX WITH DICLOFENACREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3un9 NLRX1 crystal structure of an immune receptor 2.65Å AUTH M.HONG,S.I.YOON,I.A.WILSONTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE RNA-BINDINGTITL 2 ELEMENT OF THE NLRX1 INNATE IMMUNE MODULATOR.REF IMMUNITY V. 36 337 2012REFN ISSN 1074-7613PMID 22386589DOI 10.1016/J.IMMUNI.2011.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants