General Structure Information
| PDB ID | 4a0d |
| HGNC Gene Label(s) | PARG |
| Structure Name | structure of unliganded human parg catalytic domain |
| Resolution | 1.75Å |
| Reference | AUTH J.A.TUCKER,N.BENNETT,C.BRASSINGTON,S.T.DURANT,G.HASSALL,AUTH 2 G.HOLDGATE,M.MCALISTER,J.W.M.NISSINK,C.TRUMAN,M.WATSONTITL STRUCTURES OF THE HUMAN POLY (ADP-RIBOSE) GLYCOHYDROLASETITL 2 CATALYTIC DOMAIN CONFIRM CATALYTIC MECHANISM AND EXPLAINTITL 3 INHIBITION BY ADP-HPD DERIVATIVES.REF PLOS ONE V. 7 50889 2012REFN ISSN 1932-6203PMID 23251397DOI 10.1371/JOURNAL.PONE.0050889 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 507 |
| Number Of SNVs | 38 |
| Number Of Permutations | 26505 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.074 |
| p-value | 0.616 |
COSMIC
| Number Of Residues | 507 |
| Number Of SNVs | 6 |
| Number Of Permutations | 3884 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.067 |
| p-value | 0.221 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.099 |
| p-value | 0.579 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
