General Structure Information
| PDB ID | 3hbw |
| HGNC Gene Label(s) | FGF13 |
| Structure Name | crystal structure of human fibroblast growth factor homologous factor 2a (fhf2a), also referred to as fibroblast growth factor 13a (fgf13a) |
| Resolution | 1.9Å |
| Reference | AUTH R.GOETZ,K.DOVER,F.LAEZZA,N.SHTRAIZENT,X.HUANG,AUTH 2 D.TCHETCHIK,A.V.ELISEENKOVA,C.F.XU,T.A.NEUBERT,AUTH 3 D.M.ORNITZ,M.GOLDFARB,M.MOHAMMADITITL CRYSTAL STRUCTURE OF A FIBROBLAST GROWTH FACTORTITL 2 HOMOLOGOUS FACTOR (FHF) DEFINES A CONSERVED SURFACETITL 3 ON FHFS FOR BINDING AND MODULATION OF VOLTAGE-GATEDTITL 4 SODIUM CHANNELS.REF J.BIOL.CHEM. V. 284 17883 2009REFN ISSN 0021-9258PMID 19406745DOI 10.1074/JBC.M109.001842 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 149 |
| Number Of SNVs | 8 |
| Number Of Permutations | 584 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.036 |
| p-value | 0.019 |
COSMIC
| Number Of Residues | 149 |
| Number Of SNVs | 4 |
| Number Of Permutations | 90 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 8 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.131 |
| p-value | 0.892 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
