General Structure Information
| PDB ID | 2wm1 |
| HGNC Gene Label(s) | ACMSD |
| Structure Name | the crystal structure of human alpha-amino-beta- carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between nad synthesis and glycolysis |
| Resolution | 2.01Å |
| Reference | AUTH S.GARAVAGLIA,S.PEROZZI,L.GALEAZZI,N.RAFFAELLI,AUTH 2 M.RIZZITITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA-AMINO-BETA-TITL 2 CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASETITL 3 IN COMPLEX WITH 1,3-DIHYDROXYACETONEPHOSPHATETITL 4 SUGGESTS A REGULATORY LINK BETWEEN NAD SYNTHESISTITL 5 AND GLYCOLYSISREF FEBS J. V. 276 6615 2009REFN ISSN 1742-464XPMID 19843166DOI 10.1111/J.1742-4658.2009.07372.X |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 332 |
| Number Of SNVs | 97 |
| Number Of Permutations | 37626 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.119 |
| p-value | 0.606 |
COSMIC
| Number Of Residues | 332 |
| Number Of SNVs | 9 |
| Number Of Permutations | 2194 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.028 |
| p-value | 0.528 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 97 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.066 |
| p-value | 0.385 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
