General Structure Information
| PDB ID | 3ii7 |
| HGNC Gene Label(s) | KLHL7 |
| Structure Name | crystal structure of the kelch domain of human klhl7 |
| Resolution | 1.63Å |
| Reference | AUTH P.CANNING,C.D.COOPER,T.KROJER,J.W.MURRAY,A.C.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,AUTH 3 V.AYINAMPUDI,B.D.MARSDEN,O.GILEADI,S.KNAPP,F.VON DELFT,AUTH 4 A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 PROTEIN ASSEMBLY WITH THETITL 2 BTB-KELCH FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 288 |
| Number Of SNVs | 32 |
| Number Of Permutations | 3169 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.264 |
| p-value | 0.462 |
COSMIC
| Number Of Residues | 288 |
| Number Of SNVs | 3 |
| Number Of Permutations | 160 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.667 |
| p-value | 0.824 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 32 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.348 |
| p-value | 0.044 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
