Assessment of Structural Intolerance and Durability
General Structure Information 3f5n SERPINI1 structure of native human neuroserpin 3.15Å AUTH S.RICAGNO,S.CACCIA,G.SORRENTINO,G.ANTONINI,M.BOLOGNESITITL HUMAN NEUROSERPIN: STRUCTURE AND TIME-DEPENDENT INHIBITIONREF J.MOL.BIOL. V. 388 109 2009REFN ISSN 0022-2836PMID 19265707DOI 10.1016/J.JMB.2009.02.056 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4n4w SMO structure of the human smoothened receptor in complex with sant-1. 2.8Å AUTH C.WANG,H.WU,T.EVRON,E.VARDY,G.W.HAN,X.P.HUANG,S.J.HUFEISEN,AUTH 2 T.J.MANGANO,D.J.URBAN,V.KATRITCH,V.CHEREZOV,M.G.CARON,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL BASIS FOR SMOOTHENED RECEPTOR MODULATION ANDTITL 2 CHEMORESISTANCE TO ANTICANCER DRUGS.REF NAT COMMUN V. 5 4355 2014REFN ESSN 2041-1723PMID 25008467DOI 10.1038/NCOMMS5355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2efl FNBP1 crystal structure of the efc domain of formin-binding protein 17 2.61Å AUTH A.SHIMADA,H.NIWA,K.TSUJITA,S.SUETSUGU,K.NITTA,AUTH 2 K.HANAWA-SUETSUGU,R.AKASAKA,Y.NISHINO,M.TOYAMA,L.CHEN,AUTH 3 Z.-J.LIU,B.-C.WANG,M.YAMAMOTO,T.TERADA,A.MIYAZAWA,A.TANAKA,AUTH 4 S.SUGANO,M.SHIROUZU,K.NAGAYAMA,T.TAKENAWA,S.YOKOYAMATITL CURVED EFC/F-BAR-DOMAIN DIMERS ARE JOINED END TO END INTO ATITL 2 FILAMENT FOR MEMBRANE INVAGINATION IN ENDOCYTOSISREF CELL(CAMBRIDGE,MASS.) V. 129 761 2007REFN ISSN 0092-8674PMID 17512409DOI 10.1016/J.CELL.2007.03.040 Variant Set Distributions Ripley’s K […]
General Structure Information 2ybt CHIA crystal structure of human acidic chitinase in complex with bisdionin c 2.22Å AUTH T.E.SUTHERLAND,O.A.ANDERSEN,M.BETOU,I.M.EGGLESTON,AUTH 2 R.M.MAIZELS,D.VAN AALTEN,J.E.ALLENTITL ANALYZING AIRWAY INFLAMMATION WITH CHEMICAL BIOLOGY:TITL 2 DISSECTION OF ACIDIC MAMMALIAN CHITINASE FUNCTION WITH ATITL 3 SELECTIVE DRUG-LIKE INHIBITOR.REF CHEM.BIOL. V. 18 569 2011REFN ISSN 1074-5521PMID 21609838DOI 10.1016/J.CHEMBIOL.2011.02.017 Variant Set Distributions Ripley’s K […]
General Structure Information 3rk6 PAIP1 crystal structure of the middle domain of human paip1 2.0Å AUTH J.LEI,J.R.MESTERS,A.BRUNN,R.HILGENFELDTITL CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMANTITL 2 POLY(A)-BINDING PROTEIN-INTERACTING PROTEIN 1.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 408 680 2011REFN ISSN 0006-291XPMID 21539810DOI 10.1016/J.BBRC.2011.04.088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3o4r DHRS4 crystal structure of human dehydrogenase/reductase (sdr family) member 4 (dhrs4) 1.7Å AUTH E.UGOCHUKWU,C.BHATIA,T.KROJER,M.VOLLMAR,W.W.YUE,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN DEHYDROGENASE/REDUCTASE (SDRTITL 2 FAMILY) MEMBER 4 (DHRS4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zix MUS81 crystal structure of the mus81-eme1 complex 3.5Å AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l9r NKX3-1 solution nmr structure of homeobox domain of homeobox protein nkx-3.1 from homo sapiens, northeast structural genomics consortium target hr6470a -1.0Å AUTH G.LIU,R.XIAO,H.-W.LEE,K.HAMILTON,C.CICCOSANTI,H.B.WANG,AUTH 2 T.B.ACTON,J.K.EVERETT,Y.J.HUANG,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HOMEOBOXTITL 2 PROTEIN NKX-3.1 FROM HOMO SAPIENS, NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR6470AREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2x6u TBX5 crystal structure of human tbx5 in the dna-free form 1.9Å AUTH C.U.STIRNIMANN,D.PTCHELKINE,C.GRIMM,C.W.MULLERTITL STRUCTURAL BASIS OF TBX5-DNA RECOGNITION: THE T-TITL 2 BOX DOMAIN IN ITS DNA-BOUND AND -UNBOUND FORM.REF J.MOL.BIOL. V. 400 71 2010REFN ISSN 0022-2836PMID 20450920DOI 10.1016/J.JMB.2010.04.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4gs9 EPAS1 crystal structure of the high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains in complex with an inactive benzoxadiazole antagonist 1.72Å AUTH J.L.ROGERS,L.BAYEH,T.H.SCHEUERMANN,J.LONGGOOD,J.KEY,AUTH 2 J.NAIDOO,L.MELITO,C.SHOKRI,D.E.FRANTZ,R.K.BRUICK,AUTH 3 K.H.GARDNER,J.B.MACMILLAN,U.K.TAMBARTITL DEVELOPMENT OF INHIBITORS OF THE PAS-B DOMAIN OF THE HIF-2TITL 2 ALPHA TRANSCRIPTION FACTORREF J.MED.CHEM. V. 56 1739 2013REFN ISSN 0022-2623PMID […]