Assessment of Structural Intolerance and Durability
General Structure Information 2m0c ALX4 solution nmr structure of homeobox domain of human alx4, northeast structural genomics consortium (nesg) target hr4490c -1.0Å AUTH X.XU,A.ELETSKY,S.PULAVARTI,D.LEE,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HUMAN ALX4,TITL 2 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 3 HR4490CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2de0 FUT8 crystal structure of human alpha 1,6-fucosyltransferase, fut8 2.61Å AUTH H.IHARA,Y.IKEDA,S.TOMA,X.WANG,T.SUZUKI,J.GU,E.MIYOSHI,AUTH 2 T.TSUKIHARA,K.HONKE,A.MATSUMOTO,A.NAKAGAWA,N.TANIGUCHITITL CRYSTAL STRUCTURE OF MAMMALIANTITL 2 {ALPHA}1,6-FUCOSYLTRANSFERASE, FUT8REF GLYCOBIOLOGY V. 17 455 2007REFN ISSN 0959-6658PMID 17172260DOI 10.1093/GLYCOB/CWL079 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2heh KIF2C crystal structure of the kif2c motor domain (casp target) 2.15Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KIF2C MOTOR DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zd1 SULT4A1 human sulfortransferase sult4a1 2.24Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4apc NEK1 crystal structure of human nima-related kinase 1 (nek1) 2.1Å AUTH J.M.ELKINS,T.D.M.HANCHUK,D.V.LOVATO,F.L.BASEI,G.V.MEIRELLES,AUTH 2 J.KOBARG,M.SZKLARZ,M.VOLLMAR,P.MAHAJAN,P.RELLOS,Y.ZHANG,AUTH 3 T.KROJER,A.C.W.PIKE,C.BOUNTRA,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2b6f SRXN1 solution structure of human sulfiredoxin (srx) -1.0Å AUTH D.-Y.LEE,S.J.PARK,W.JEONG,H.J.SUNG,T.OHO,X.WU,AUTH 2 S.G.RHEE,J.M.GRUSCHUSTITL MUTAGENESIS AND MODELING OF THE PEROXIREDOXINTITL 2 (PRX) COMPLEX WITH THE NMR STRUCTURE OF ATP-BOUNDTITL 3 HUMAN SULFIREDOXIN IMPLICATE ASPARTATE 187 OF PRXTITL 4 I AS THE CATALYTIC RESIDUE IN ATP HYDROLYSISREF BIOCHEMISTRY V. 45 15301 2006REFN ISSN 0006-2960PMID […]
General Structure Information 4gl2 IFIH1 structural basis for dsrna duplex backbone recognition by mda5 3.56Å AUTH B.WU,A.PEISLEY,C.RICHARDS,H.YAO,X.ZENG,C.LIN,F.CHU,T.WALZ,AUTH 2 S.HURTITL STRUCTURAL BASIS FOR DSRNA RECOGNITION, FILAMENT FORMATION,TITL 2 AND ANTIVIRAL SIGNAL ACTIVATION BY MDA5.REF CELL(CAMBRIDGE,MASS.) V. 152 276 2013REFN ISSN 0092-8674PMID 23273991DOI 10.1016/J.CELL.2012.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1u7t HSD17B10 crystal structure of abad/hsd10 with a bound inhibitor 2.0Å AUTH C.R.KISSINGER,P.A.REJTO,L.A.PELLETIER,J.A.THOMSON,AUTH 2 R.E.SHOWALTER,M.A.ABREO,C.S.AGREE,S.MARGOSIAK,AUTH 3 J.J.MENG,R.M.AUST,D.VANDERPOOL,B.LI,AUTH 4 A.TEMPCZYK-RUSSELL,J.E.VILLAFRANCATITL CRYSTAL STRUCTURE OF HUMAN ABAD/HSD10 WITH A BOUNDTITL 2 INHIBITOR: IMPLICATIONS FOR DESIGN OF ALZHEIMERSTITL 3 DISEASE THERAPEUTICSREF J.MOL.BIOL. V. 342 943 2004REFN ISSN 0022-2836PMID 15342248DOI 10.1016/J.JMB.2004.07.071 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4frw PVRL4 crystal structure of human nectin-4 extracellular fragment d1-d2 3.5Å AUTH O.J.HARRISON,J.VENDOME,J.BRASCH,X.JIN,S.HONG,P.S.KATSAMBA,AUTH 2 G.AHLSEN,R.B.TROYANOVSKY,S.M.TROYANOVSKY,B.HONIG,L.SHAPIROTITL NECTIN ECTODOMAIN STRUCTURES REVEAL A CANONICAL ADHESIVETITL 2 INTERFACE.REF NAT.STRUCT.MOL.BIOL. V. 19 906 2012REFN ISSN 1545-9993PMID 22902367DOI 10.1038/NSMB.2366 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ag5 BDH2 crystal structure of human dhrs6 1.84Å AUTH K.GUO,P.LUKACIK,E.PAPAGRIGORIOU,M.MEIER,W.H.LEE,J.ADAMSKI,AUTH 2 U.OPPERMANNTITL CHARACTERIZATION OF HUMAN DHRS6, AN ORPHAN SHORT CHAINTITL 2 DEHYDROGENASE/REDUCTASE ENZYME: A NOVEL, CYTOSOLIC TYPE 2TITL 3 R-BETA-HYDROXYBUTYRATE DEHYDROGENASEREF J.BIOL.CHEM. V. 281 10291 2006REFN ISSN 0021-9258PMID 16380372DOI 10.1074/JBC.M511346200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]