General Structure Information
| PDB ID | 2m0c |
| HGNC Gene Label(s) | ALX4 |
| Structure Name | solution nmr structure of homeobox domain of human alx4, northeast structural genomics consortium (nesg) target hr4490c |
| Resolution | -1.0Å |
| Reference | AUTH X.XU,A.ELETSKY,S.PULAVARTI,D.LEE,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HUMAN ALX4,TITL 2 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 3 HR4490CREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 72 |
| Number Of SNVs | 13 |
| Number Of Permutations | 1135 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.026 |
| p-value | 0.426 |
ClinVar
| Number Of Residues | 72 |
| Number Of SNVs | 4 |
| Number Of Permutations | 183 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.0 |
| p-value | 0.517 |
COSMIC
| Number Of Residues | 72 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1588 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.286 |
| p-value | 0.366 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.167 |
| p-value | 0.472 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.07 |
| p-value | 0.805 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
