General Structure Information
| PDB ID | 4n4w |
| HGNC Gene Label(s) | SMO |
| Structure Name | structure of the human smoothened receptor in complex with sant-1. |
| Resolution | 2.8Å |
| Reference | AUTH C.WANG,H.WU,T.EVRON,E.VARDY,G.W.HAN,X.P.HUANG,S.J.HUFEISEN,AUTH 2 T.J.MANGANO,D.J.URBAN,V.KATRITCH,V.CHEREZOV,M.G.CARON,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL BASIS FOR SMOOTHENED RECEPTOR MODULATION ANDTITL 2 CHEMORESISTANCE TO ANTICANCER DRUGS.REF NAT COMMUN V. 5 4355 2014REFN ESSN 2041-1723PMID 25008467DOI 10.1038/NCOMMS5355 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 348 |
| Number Of SNVs | 68 |
| Number Of Permutations | 20925 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.019 |
| p-value | 0.947 |
COSMIC
| Number Of Residues | 348 |
| Number Of SNVs | 11 |
| Number Of Permutations | 9912 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.218 |
| p-value | 0.095 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 68 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.153 |
| p-value | 0.236 |