Assessment of Structural Intolerance and Durability
General Structure Information 3qe9 EXO1 crystal structure of human exonuclease 1 exo1 (d173a) in complex with dna (complex i) 2.51Å AUTH J.ORANS,E.A.MCSWEENEY,R.R.IYER,M.A.HAST,H.W.HELLINGA,AUTH 2 P.MODRICH,L.S.BEESETITL STRUCTURES OF HUMAN EXONUCLEASE 1 DNA COMPLEXES SUGGEST ATITL 2 UNIFIED MECHANISM FOR NUCLEASE FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 212 2011REFN ISSN 0092-8674PMID 21496642DOI 10.1016/J.CELL.2011.03.005 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2q8k PA2G4 the crystal structure of ebp1 1.6Å AUTH E.KOWALINSKI,G.BANGE,B.BRADATSCH,E.HURT,K.WILD,I.SINNINGTITL THE CRYSTAL STRUCTURE OF EBP1 REVEALS A METHIONINETITL 2 AMINOPEPTIDASE FOLD AS BINDING PLATFORM FOR MULTIPLETITL 3 INTERACTIONS.REF FEBS LETT. V. 581 4450 2007REFN ISSN 0014-5793PMID 17765895DOI 10.1016/J.FEBSLET.2007.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3soa CAMK2A full-length human camkii 3.55Å AUTH L.H.CHAO,M.M.STRATTON,I.H.LEE,O.S.ROSENBERG,J.LEVITZ,AUTH 2 D.J.MANDELL,T.KORTEMME,J.T.GROVES,H.SCHULMAN,J.KURIYANTITL A MECHANISM FOR TUNABLE AUTOINHIBITION IN THE STRUCTURE OF ATITL 2 HUMAN CA(2+)/CALMODULIN- DEPENDENT KINASE II HOLOENZYME.REF CELL(CAMBRIDGE,MASS.) V. 146 732 2011REFN ISSN 0092-8674PMID 21884935DOI 10.1016/J.CELL.2011.07.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4g8a LY96 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3f3s CRYL1 the crystal structure of human lambda-crystallin, cryl1 2.0Å AUTH E.UGOCHUKWU,C.JOHANSSON,W.W.YUE,G.KOCHAN,E.PILKA,A.KRAMM,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,F.VON DELFT,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN LAMBDA-CRYSTALLIN, CRYL1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4jz1 ST14 crystal structure of matriptase in complex with inhibitor 1.9Å AUTH R.GOSWAMI,S.MUKHERJEE,G.WOHLFAHRT,C.GHADIYARAM,J.NAGARAJ,AUTH 2 B.R.CHANDRA,R.K.SISTLA,L.K.SATYAM,D.S.SAMIULLA,A.MOILANEN,AUTH 3 H.S.SUBRAMANYA,M.RAMACHANDRATITL DISCOVERY OF PYRIDYL BIS(OXY)DIBENZIMIDAMIDE DERIVATIVES ASTITL 2 SELECTIVE MATRIPTASE INHIBITORSREF ACS MED.CHEM.LETT. V. 4 1152 2013REFN ISSN 1948-5875PMID 24900621DOI 10.1021/ML400213V Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ap6 POFUT2 crystal structure of human pofut2 e54a mutant in complex with gdp- fucose 3.401Å AUTH C.I.CHEN,J.J.KEUSCH,D.KLEIN,D.HESS,J.HOFSTEENGE,H.GUTTITL STRUCTURE OF HUMAN POFUT2: INSIGHTS INTO THROMBOSPONDINTITL 2 TYPE 1 REPEAT FOLD AND O-FUCOSYLATION.REF EMBO J. V. 31 3183 2012REFN ISSN 0261-4189PMID 22588082DOI 10.1038/EMBOJ.2012.143 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3fg6 SCIN structure of the c-terminus of adseverin 3.0Å AUTH S.CHUMNARNSILPA,W.L.LEE,S.NAG,B.KANNAN,M.LARSSON,AUTH 2 L.D.BURTNICK,R.C.ROBINSONTITL THE CRYSTAL STRUCTURE OF THE C-TERMINUS OF ADSEVERIN REVEALSTITL 2 THE ACTIN-BINDING INTERFACE.REF PROC.NATL.ACAD.SCI.USA V. 106 13719 2009REFN ISSN 0027-8424PMID 19666531DOI 10.1073/PNAS.0812383106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ihr UCHL5 crystal structure of uch37 2.95Å AUTH S.E.BURGIE,C.A.BINGMAN,A.B.SONI,G.N.PHILLIPSTITL STRUCTURAL CHARACTERIZATION OF HUMAN UCH37.REF PROTEINS 2011REFN ESSN 1097-0134PMID 21953935DOI 10.1002/PROT.23147 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2izs CSNK1G3 structure of casein kinase gamma 3 in complex with inhibitor 1.95Å AUTH G.BUNKOCZI,E.SALAH,P.RELLOS,S.DAS,O.FEDOROV,P.SAVITSKY,AUTH 2 J.E.DEBRECZENI,O.GILEADI,M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,AUTH 3 J.WEIGELT,F.VON DELFT,S.KNAPPTITL INHIBITOR BINDING BY CASEIN KINASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants