General Structure Information
| PDB ID | 4g8a |
| HGNC Gene Label(s) | LY96 |
| Structure Name | crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps |
| Resolution | 2.4Å |
| Reference | AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 140 |
| Number Of SNVs | 33 |
| Number Of Permutations | 2686 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.053 |
| p-value | 0.21 |
COSMIC
| Number Of Residues | 140 |
| Number Of SNVs | 4 |
| Number Of Permutations | 43 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.167 |
| p-value | 0.876 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.422 |
| p-value | 0.153 |