General Structure Information
| PDB ID | 4jz1 |
| HGNC Gene Label(s) | ST14 |
| Structure Name | crystal structure of matriptase in complex with inhibitor |
| Resolution | 1.9Å |
| Reference | AUTH R.GOSWAMI,S.MUKHERJEE,G.WOHLFAHRT,C.GHADIYARAM,J.NAGARAJ,AUTH 2 B.R.CHANDRA,R.K.SISTLA,L.K.SATYAM,D.S.SAMIULLA,A.MOILANEN,AUTH 3 H.S.SUBRAMANYA,M.RAMACHANDRATITL DISCOVERY OF PYRIDYL BIS(OXY)DIBENZIMIDAMIDE DERIVATIVES ASTITL 2 SELECTIVE MATRIPTASE INHIBITORSREF ACS MED.CHEM.LETT. V. 4 1152 2013REFN ISSN 1948-5875PMID 24900621DOI 10.1021/ML400213V |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 227 |
| Number Of SNVs | 56 |
| Number Of Permutations | 17862 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.062 |
| p-value | 0.02 |
COSMIC
| Number Of Residues | 227 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.751 |
| p-value | 0.122 |