Assessment of Structural Intolerance and Durability
General Structure Information 1hnf CD2 crystal structure of the extracellular region of the human cell adhesion molecule cd2 at 2.5 angstroms resolution 2.5Å AUTH D.L.BODIAN,E.Y.JONES,K.HARLOS,D.I.STUART,S.J.DAVISTITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMANTITL 2 CELL ADHESION MOLECULE CD2 AT 2.5 A RESOLUTION.REF STRUCTURE V. 2 755 1994REFN ISSN 0969-2126PMID 7994575DOI 10.1016/S0969-2126(94)00076-X Variant Set Distributions […]
General Structure Information 4j1y C1S the x-ray crystal structure of human complement protease c1s zymogen 2.66Å AUTH A.J.PERRY,L.C.WIJEYEWICKREMA,P.G.WILMANN,M.J.GUNZBURG,AUTH 2 L.DANDREA,J.A.IRVING,S.S.PANG,R.C.DUNCAN,J.A.WILCE,AUTH 3 J.C.WHISSTOCK,R.N.PIKETITL A MOLECULAR SWITCH GOVERNS THE INTERACTION BETWEEN THE HUMANTITL 2 COMPLEMENT PROTEASE C1S AND ITS SUBSTRATE, COMPLEMENT C4.REF J.BIOL.CHEM. V. 288 15821 2013REFN ISSN 0021-9258PMID 23592783DOI 10.1074/JBC.M113.464545 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3vi4 ITGA5 crystal structure of alpha5beta1 integrin headpiece in complex with rgd peptide 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2pip AR androgen receptor lbd with small molecule 1.8Å AUTH E.ESTEBANEZ-PERPINA,L.A.ARNOLD,A.A.ARNOLD,P.NGUYEN,AUTH 2 E.D.RODRIGUES,E.MAR,R.BATEMAN,P.PALLAI,K.M.SHOKAT,AUTH 3 J.D.BAXTER,R.K.GUY,P.WEBB,R.J.FLETTERICKTITL A SURFACE ON THE ANDROGEN RECEPTOR THATTITL 2 ALLOSTERICALLY REGULATES COACTIVATOR BINDING.REF PROC.NATL.ACAD.SCI.USA V. 104 16074 2007REFN ISSN 0027-8424PMID 17911242DOI 10.1073/PNAS.0708036104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2e9w KIT crystal structure of the extracellular domain of kit in complex with stem cell factor (scf) 3.5Å AUTH S.YUZAWA,Y.OPATOWSKY,Z.ZHANG,V.MANDIYAN,I.LAX,J.SCHLESSINGERTITL STRUCTURAL BASIS FOR ACTIVATION OF THE RECEPTOR TYROSINETITL 2 KINASE KIT BY STEM CELL FACTORREF CELL(CAMBRIDGE,MASS.) V. 130 323 2007REFN ISSN 0092-8674PMID 17662946DOI 10.1016/J.CELL.2007.05.055 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1nq0 THRB tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd 2.4Å AUTH B.R.HUBER,M.DESCLOZEAUX,B.L.WEST,S.T.CUNHA-LIMA,H.T.NGUYEN,AUTH 2 J.D.BAXTER,H.A.INGRAHAM,R.J.FLETTERICKTITL THYROID HORMONE RECEPTOR-BETA MUTATIONS CONFERRING HORMONETITL 2 RESISTANCE AND REDUCED COREPRESSOR RELEASE EXHIBIT DECREASEDTITL 3 STABILITY IN THE N-TERMINAL LIGAND-BINDING DOMAINREF MOL.ENDOCRINOL. V. 17 107 2003REFN ISSN 0888-8809PMID […]
General Structure Information 3ujr ENO2 asymmetric complex of human neuron specific enolase-5-pga/pep 1.4Å AUTH J.QIN,G.CHAI,J.M.BREWER,L.L.LOVELACE,L.LEBIODATITL STRUCTURES OF ASYMMETRIC COMPLEXES OF HUMAN NEURON SPECIFICTITL 2 ENOLASE WITH RESOLVED SUBSTRATE AND PRODUCT AND AN ANALOGOUSTITL 3 COMPLEX WITH TWO INHIBITORS INDICATE SUBUNIT INTERACTION ANDTITL 4 INHIBITOR COOPERATIVITY.REF J.INORG.BIOCHEM. V. 111 187 2012REFN ISSN 0162-0134PMID 22437160DOI 10.1016/J.JINORGBIO.2012.02.011 Variant […]
General Structure Information 1l5s PYGL human liver glycogen phosphorylase complexed with uric acid, n-acetyl- beta-d-glucopyranosylamine, and cp-403,700 2.1Å AUTH J.L.EKSTROM,T.A.PAULY,M.D.CARTY,W.C.SOELLER,J.CULP,AUTH 2 D.E.DANLEY,D.J.HOOVER,J.L.TREADWAY,E.M.GIBBS,R.J.FLETTERICK,AUTH 3 Y.S.DAY,D.G.MYSZKA,V.L.RATHTITL STRUCTURE-ACTIVITY ANALYSIS OF THE PURINE BINDING SITE OFTITL 2 HUMAN LIVER GLYCOGEN PHOSPHORYLASE.REF CHEM.BIOL. V. 9 915 2002REFN ISSN 1074-5521PMID 12204691DOI 10.1016/S1074-5521(02)00186-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3fcs ITGA2B structure of complete ectodomain of integrin aiibb3 2.55Å AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1hdr QDPR the crystallographic structure of a human dihydropteridine reductase nadh binary complex expressed in escherichia coli by a cdna constructed from its rat homologue 2.5Å AUTH Y.SU,K.I.VARUGHESE,N.H.XUONG,T.L.BRAY,D.J.ROCHE,J.M.WHITELEYTITL THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINETITL 2 REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLITITL 3 BY A CDNA CONSTRUCTED FROM ITS RAT […]