General Structure Information
| PDB ID | 2pip |
| HGNC Gene Label(s) | AR |
| Structure Name | androgen receptor lbd with small molecule |
| Resolution | 1.8Å |
| Reference | AUTH E.ESTEBANEZ-PERPINA,L.A.ARNOLD,A.A.ARNOLD,P.NGUYEN,AUTH 2 E.D.RODRIGUES,E.MAR,R.BATEMAN,P.PALLAI,K.M.SHOKAT,AUTH 3 J.D.BAXTER,R.K.GUY,P.WEBB,R.J.FLETTERICKTITL A SURFACE ON THE ANDROGEN RECEPTOR THATTITL 2 ALLOSTERICALLY REGULATES COACTIVATOR BINDING.REF PROC.NATL.ACAD.SCI.USA V. 104 16074 2007REFN ISSN 0027-8424PMID 17911242DOI 10.1073/PNAS.0708036104 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 249 |
| Number Of SNVs | 23 |
| Number Of Permutations | 11314 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.067 |
| p-value | 0.645 |
ClinVar
| Number Of Residues | 249 |
| Number Of SNVs | 23 |
| Number Of Permutations | 11401 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.277 |
| p-value | 0.07 |
COSMIC
| Number Of Residues | 249 |
| Number Of SNVs | 6 |
| Number Of Permutations | 372 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 0.585 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of ClinVar SNVs | 23 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.099 |
| p-value | 0.08 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.4 |
| p-value | 0.089 |