Assessment of Structural Intolerance and Durability
General Structure Information 2gli GLI1 five-finger gli/dna complex 2.6Å AUTH N.P.PAVLETICH,C.O.PABOTITL CRYSTAL STRUCTURE OF A FIVE-FINGER GLI-DNATITL 2 COMPLEX: NEW PERSPECTIVES ON ZINC FINGERS.REF SCIENCE V. 261 1701 1993REFN ISSN 0036-8075PMID 8378770 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2zoc ANXA4 crystal structure of recombinant human annexin iv 2.0Å AUTH M.KONNO,Y.KANEKO-KANZAKI,N.FUSHINOBU-OKUSHI,AUTH 2 K.MOCHIZUKI,E.UCHIKAWA,A.SATOH,K.AIKAWATITL THE COMPARISON OF THE LOOP STRUCTURE OF MEMBRANETITL 2 BINDING SITES BETWEEN HUMAN AND BOVINE ANNEXIN IVREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3th4 F7 mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+ 1.8Å AUTH K.VADIVEL,S.AGAH,A.MESSER,D.CASCIO,S.M.BAJAJ,S.KRISHNASWAMY,AUTH 2 C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THETITL 2 GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMINTITL 3 K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+REF TO BE PUBLISHEDREFN […]
General Structure Information 4el1 P4HB crystal structure of oxidized hpdi (abbxa) 2.88Å AUTH C.WANG,W.LI,J.REN,J.FANG,H.KE,W.GONG,W.FENG,C.-C.WANGTITL STRUCTURAL INSIGHTS INTO THE REDOX-REGULATED DYNAMICTITL 2 CONFORMATIONS OF HUMAN PROTEIN DISULFIDE ISOMERASEREF ANTIOXID REDOX SIGNAL V. 19 44 2013REFN ISSN 1557-7716PMID 22657537DOI 10.1089/ARS.2012.4630 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ke5 RALB solution structure and dynamics of the small gtpase ralb in its active conformation: significance for effector protein binding -1.0Å AUTH R.B.FENWICK,S.PRASANNAN,L.J.CAMPBELL,D.NIETLISPACH,AUTH 2 K.A.EVETTS,J.CAMONIS,H.R.MOTT,D.OWENTITL SOLUTION STRUCTURE AND DYNAMICS OF THE SMALL GTPASETITL 2 RALB IN ITS ACTIVE CONFORMATION: SIGNIFICANCE FORTITL 3 EFFECTOR PROTEIN BINDINGREF BIOCHEMISTRY V. 48 2192 2009REFN ISSN 0006-2960PMID […]
General Structure Information 2wsl BCHE aged form of human butyrylcholinesterase inhibited by tabun analogue ta4 2.0Å AUTH E.CARLETTI,N.AURBEK,E.GILLON,M.LOIODICE,Y.NICOLET,AUTH 2 J.C.FONTECILLA-CAMPS,P.MASSON,H.THIERMANN,F.NACHON,F.WOREKTITL STRUCTURE-ACTIVITY ANALYSIS OF AGING AND REACTIVATION OFTITL 2 HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY ANALOGUES OFTITL 3 TABUN.REF BIOCHEM.J. V. 421 97 2009REFN ISSN 0264-6021PMID 19368529DOI 10.1042/BJ20090091 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1p49 STS structure of human placental estrone/dhea sulfatase 2.6Å AUTH F.G.HERNANDEZ-GUZMAN,T.HIGASHIYAMA,W.PANGBORN,Y.OSAWA,AUTH 2 D.GHOSHTITL STRUCTURE OF HUMAN ESTRONE SULFATASE SUGGESTS FUNCTIONALTITL 2 ROLES OF MEMBRANE ASSOCIATIONREF J.BIOL.CHEM. V. 278 22989 2003REFN ISSN 0021-9258PMID 12657638DOI 10.1074/JBC.M211497200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4h5n HSPA8 hsc70 nbd with po4, na, cl 1.86Å AUTH Z.ZHANG,J.CELLITTI,P.TERIETE,M.PELLECCHIA,B.STECTITL NEW CRYSTAL STRUCTURES OF HSC-70 ATP BINDING DOMAIN CONFIRMTITL 2 THE ROLE OF INDIVIDUAL BINDING POCKETS AND SUGGEST A NEWTITL 3 METHOD OF INHIBITION.REF BIOCHIMIE V. 108 186 2015REFN ISSN 0300-9084PMID 25433210DOI 10.1016/J.BIOCHI.2014.11.012 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3mjg PDGFRB the structure of a platelet derived growth factor receptor complex 2.3Å AUTH A.H.SHIM,H.LIU,P.J.FOCIA,X.CHEN,P.C.LIN,X.HETITL STRUCTURES OF A PLATELET-DERIVED GROWTH FACTOR/PROPEPTIDETITL 2 COMPLEX AND A PLATELET-DERIVED GROWTH FACTOR/RECEPTORTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 11307 2010REFN ISSN 0027-8424PMID 20534510DOI 10.1073/PNAS.1000806107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3fcx ESD crystal structure of human esterase d 1.5Å AUTH D.WU,Y.LI,G.SONG,D.ZHANG,N.SHAW,Z.J.LIUTITL CRYSTAL STRUCTURE OF HUMAN ESTERASE D: A POTENTIALTITL 2 GENETIC MARKER OF RETINOBLASTOMAREF FASEB J. V. 23 1441 2009REFN ISSN 0892-6638PMID 19126594DOI 10.1096/FJ.08-125286 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants