Assessment of Structural Intolerance and Durability
General Structure Information 2h32 VPREB1 crystal structure of the pre-b cell receptor 2.7Å AUTH A.J.BANKOVICH,S.RAUNSER,Z.S.JUO,T.WALZ,M.M.DAVIS,K.C.GARCIATITL STRUCTURAL INSIGHT INTO PRE-B CELL RECEPTOR FUNCTIONREF SCIENCE V. 316 291 2007REFN ISSN 0036-8075PMID 17431183DOI 10.1126/SCIENCE.1139412 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ii0 GOT1 crystal structure of human glutamate oxaloacetate transaminase 1 (got1) 2.05Å AUTH E.UGOCHUKWU,E.PILKA,C.COOPER,J.E.BRAY,W.W.YUE,J.MUNIZ,AUTH 2 A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTAMATE OXALOACETATETITL 2 TRANSAMINASE 1 (GOT1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fbn PLCG1 insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of sh2 domains 2.4Å AUTH T.D.BUNNEY,D.ESPOSITO,C.MAS-DROUX,E.LAMBER,R.W.BAXENDALE,AUTH 2 M.MARTINS,A.COLE,D.SVERGUN,P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND FUNCTIONAL INTEGRATION OF THE PLCGAMMATITL 2 INTERACTION DOMAINS CRITICAL FOR REGULATORY MECHANISMS ANDTITL 3 SIGNALING DEREGULATION.REF STRUCTURE V. 20 2062 2012REFN […]
General Structure Information 4j15 DARS crystal structure of human cytosolic aspartyl-trna synthetase, a component of multi-trna synthetase complex 2.24Å AUTH K.R.KIM,S.H.PARK,H.S.KIM,K.H.RHEE,B.-G.KIM,D.G.KIM,M.S.PARK,AUTH 2 H.-J.KIM,S.KIM,B.W.HANTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ASPARTYL-TRNATITL 2 SYNTHETASE, A COMPONENT OF MULTI-TRNA SYNTHETASE COMPLEXREF PROTEINS V. 81 1840 2013REFN ISSN 0887-3585PMID 23609930DOI 10.1002/PROT.24306 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1g9l PABPC1 solution structure of the pabc domain of human poly(a) binding protein -1.0Å AUTH G.KOZLOV,J.F.TREMPE,K.KHALEGHPOUR,A.KAHVEJIAN,AUTH 2 I.EKIEL,K.GEHRINGTITL STRUCTURE AND FUNCTION OF THE C-TERMINAL PABCTITL 2 DOMAIN OF HUMAN POLY(A)-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 98 4409 2001REFN ISSN 0027-8424PMID 11287632DOI 10.1073/PNAS.071024998 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4g84 HARS crystal structure of human hisrs 2.4Å AUTH Z.XU,Z.WEI,J.J.ZHOU,F.YE,W.S.LO,F.WANG,C.F.LAU,J.WU,AUTH 2 L.A.NANGLE,K.P.CHIANG,X.L.YANG,M.ZHANG,P.SCHIMMELTITL INTERNALLY DELETED HUMAN TRNA SYNTHETASE SUGGESTSTITL 2 EVOLUTIONARY PRESSURE FOR REPURPOSING.REF STRUCTURE V. 20 1470 2012REFN ISSN 0969-2126PMID 22958643DOI 10.1016/J.STR.2012.08.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4eeg B4GALT1 crystal structure of human m340h-beta-1,4-galactosyltransferase-1 (m340h-b4gal-t1) in complex with glcnac-beta1,6-gal-beta 2.2Å AUTH B.RAMAKRISHNAN,E.BOEGGEMAN,P.K.QASBATITL BINDING OF N-ACETYLGLUCOSAMINE (GLCNAC) BETA 1-6-BRANCHEDTITL 2 OLIGOSACCHARIDE ACCEPTORS TO BETA 4-GALACTOSYLTRANSFERASE ITITL 3 REVEALS A NEW LIGAND BINDING MODE.REF J.BIOL.CHEM. V. 287 28666 2012REFN ISSN 0021-9258PMID 22740701DOI 10.1074/JBC.M112.373514 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2gk2 CEACAM1 crystal structure of the n terminal domain of human ceacam1 2.2Å AUTH A.FEDAROVICH,J.TOMBERG,R.A.NICHOLAS,C.DAVIESTITL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN CEACAM1: BINDINGTITL 2 TARGET OF THE OPACITY PROTEINS DURING INVASION OF NEISSERIATITL 3 MENINGITIDIS AND N. GONORRHOEAE.REF ACTA CRYSTALLOGR.,SECT.D V. 62 971 2006REFN ISSN 0907-4449PMID 16929097DOI 10.1107/S0907444906020737 Variant Set Distributions […]
General Structure Information 4gdx GGT1 crystal structure of human gamma-glutamyl transpeptidase–glutamate complex 1.67Å AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]