Assessment of Structural Intolerance and Durability
General Structure Information 4jqg MMP9 crystal structure of an inactive mutant of mmp-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom. 1.85Å AUTH I.TRANCHANT,L.VERA,B.CZARNY,M.AMOURA,E.CASSAR,F.BEAU,AUTH 2 E.A.STURA,V.DIVETITL HALOGEN BONDING CONTROLS SELECTIVITY OF FRET SUBSTRATETITL 2 PROBES FOR MMP-9.REF CHEM.BIOL. V. 21 408 2014REFN ISSN 1074-5521PMID 24583051DOI 10.1016/J.CHEMBIOL.2014.01.008 Variant Set Distributions […]
General Structure Information 1itq DPEP1 human renal dipeptidase 2.3Å AUTH Y.NITANAI,Y.SATOW,H.ADACHI,M.TSUJIMOTOTITL CRYSTAL STRUCTURE OF HUMAN RENAL DIPEPTIDASE INVOLVED INTITL 2 BETA-LACTAM HYDROLYSISREF J.MOL.BIOL. V. 321 177 2002REFN ISSN 0022-2836PMID 12144777DOI 10.1016/S0022-2836(02)00632-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o72 CDH1 crystal structure analysis of human e-cadherin (1-213) 2.0Å AUTH E.PARISINI,J.M.G.HIGGINS,J.-H.LIU,M.B.BRENNER,AUTH 2 J.-H.WANGTITL THE CRYSTAL STRUCTURE OF HUMAN E-CADHERIN DOMAINSTITL 2 1 AND 2, AND COMPARISON WITH OTHER CADHERINS INTITL 3 THE CONTEXT OF ADHESION MECHANISMREF J.MOL.BIOL. V. 373 401 2007REFN ISSN 0022-2836PMID 17850815DOI 10.1016/J.JMB.2007.08.011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3iw4 PRKCA crystal structure of pkc alpha in complex with nvp-aeb071 2.8Å AUTH J.WAGNER,P.VON MATT,R.SEDRANI,R.ALBERT,N.COOKE,C.EHRHARDT,AUTH 2 M.GEISER,G.RUMMEL,W.STARK,A.STRAUSS,S.W.COWAN-JACOB,AUTH 3 C.BEERLI,G.WECKBECKER,J.P.EVENOU,G.ZENKE,S.COTTENSTITL DISCOVERY OFTITL 2 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-TITL 3 YL]PYRROLE-2,5-DIONE (AEB071), A POTENT AND SELECTIVETITL 4 INHIBITOR OF PROTEIN KINASE C ISOTYPESREF J.MED.CHEM. V. 52 6193 2009REFN ISSN 0022-2623PMID 19827831DOI 10.1021/JM901108B Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4db1 MYH7 cardiac human myosin s1dc, beta isoform complexed with mn-amppnp 2.6Å AUTH V.A.KLENCHIN,J.C.DEACON,A.C.COMBS,L.A.LEINWAND,I.RAYMENTTITL CARDIAC HUMAN MYOSIN S1DC, BETA ISOFORM COMPLEXED WITHTITL 2 MN-AMPPNPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dyd TAT human tyrosine aminotransferase 2.3Å AUTH T.KARLBERG,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 K.OLESEN,C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 H.SCHULER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN TYROSINE AMINOTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3akm FABP2 x-ray structure of ifabp from human and rat with bound fluorescent fatty acid analogue 1.9Å AUTH A.J.K.LAGUERRE,J.WIELENS,M.W.PARKER,C.J.PORTER,M.J.SCANLONTITL CRYSTAL STRUCTURES OF HUMAN AND RAT INTESTINAL FATTY ACIDTITL 2 BINDING PROTEINS IN COMPLEX WITH 11-(DANSYLAMINO)UNDECANOICTITL 3 ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1fsu ARSB 4-sulfatase (human) 2.5Å AUTH C.S.BOND,P.R.CLEMENTS,S.J.ASHBY,C.A.COLLYER,S.J.HARROP,AUTH 2 J.J.HOPWOOD,J.M.GUSSTITL STRUCTURE OF A HUMAN LYSOSOMAL SULFATASE.REF STRUCTURE V. 5 277 1997REFN ISSN 0969-2126PMID 9032078DOI 10.1016/S0969-2126(97)00185-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lpo SI crystal structure of the n-terminal domain of sucrase-isomaltase 3.2Å AUTH L.SIM,C.WILLEMSMA,S.MOHAN,H.Y.NAIM,B.M.PINTO,D.R.ROSETITL STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN HUMANTITL 2 MALTASE-GLUCOAMYLASE AND SUCRASE-ISOMALTASE N-TERMINALTITL 3 DOMAINS.REF J.BIOL.CHEM. V. 285 17763 2010REFN ISSN 0021-9258PMID 20356844DOI 10.1074/JBC.M109.078980 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d0u IDO1 crystal structure of cyanide bound form of human indoleamine 2,3-dioxygenase 3.4Å AUTH H.SUGIMOTO,S.ODA,T.OTSUKI,T.HINO,T.YOSHIDA,Y.SHIROTITL CRYSTAL STRUCTURE OF HUMAN INDOLEAMINETITL 2 2,3-DIOXYGENASE: CATALYTIC MECHANISM OF O2TITL 3 INCORPORATION BY A HEME-CONTAINING DIOXYGENASE.REF PROC.NATL.ACAD.SCI.USA V. 103 2611 2006REFN ISSN 0027-8424PMID 16477023DOI 10.1073/PNAS.0508996103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]