1VCA.A | VCAM1

General Structure Information 1vca VCAM1 crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 angstroms resolution 1.8Å AUTH E.Y.JONES,K.HARLOS,M.J.BOTTOMLEY,R.C.ROBINSON,AUTH 2 P.C.DRISCOLL,R.M.EDWARDS,J.M.CLEMENTS,T.J.DUDGEON,AUTH 3 D.I.STUARTTITL CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENTTITL 2 OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ATITL 3 RESOLUTION.REF NATURE V. 373 539 1995REFN ISSN 0028-0836PMID 7531291DOI 10.1038/373539A0 Variant Set […]

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3CFW.A | SELL

General Structure Information 3cfw SELL l-selectin lectin and egf domains 2.2Å AUTH P.MEHTA,R.P.MCEVERTITL STRUCTURE OF LECTIN AND EGF DOMAINS OF L-SELECTINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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1K6M.B | PFKFB1

General Structure Information 1k6m PFKFB1 crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2.4Å AUTH Y.H.LEE,Y.LI,K.UYEDA,C.A.HASEMANNTITL TISSUE-SPECIFIC STRUCTURE/FUNCTION DIFFERENTIATION OF THETITL 2 LIVER ISOFORM OFTITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE.REF J.BIOL.CHEM. V. 278 523 2003REFN ISSN 0021-9258PMID 12379646DOI 10.1074/JBC.M209105200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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2QC8.F | GLUL

General Structure Information 2qc8 GLUL crystal structure of human glutamine synthetase in complex with adp and methionine sulfoximine phosphate 2.6Å AUTH W.W.KRAJEWSKI,R.COLLINS,L.HOLMBERG-SCHIAVONE,T.A.JONES,AUTH 2 T.KARLBERG,S.L.MOWBRAYTITL CRYSTAL STRUCTURES OF MAMMALIAN GLUTAMINE SYNTHETASESTITL 2 ILLUSTRATE SUBSTRATE-INDUCED CONFORMATIONAL CHANGES ANDTITL 3 PROVIDE OPPORTUNITIES FOR DRUG AND HERBICIDE DESIGN.REF J.MOL.BIOL. V. 375 217 2008REFN ISSN 0022-2836PMID 18005987DOI 10.1016/J.JMB.2007.10.029 Variant Set […]

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2WK3.B | IDE

General Structure Information 2wk3 IDE crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) 2.59Å AUTH Q.GUO,M.MANOLOPOULOU,Y.BIAN,A.B.SCHILLING,W.J.TANGTITL MOLECULAR BASIS FOR THE RECOGNITION AND CLEAVAGESTITL 2 OF IGF-II, TGF-ALPHA, AND AMYLIN BY HUMAN INSULINTITL 3 DEGRADING ENZYME.REF J.MOL.BIOL. V. 395 430 2010REFN ISSN 0022-2836PMID 19896952DOI 10.1016/J.JMB.2009.10.072 Variant Set Distributions Ripley’s K Analysis Plots Variant […]

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4H27.A | SDS

General Structure Information 4h27 SDS modulating the function of human serine racemase and human serine dehydratase by protein engineering 1.3Å AUTH C.Y.WANG,S.C.KU,C.C.LEE,A.H.WANGTITL MODULATING THE FUNCTION OF HUMAN SERINE RACEMASE AND HUMANTITL 2 SERINE DEHYDRATASE BY PROTEIN ENGINEERING.REF PROTEIN ENG.DES.SEL. V. 25 741 2012REFN ISSN 1741-0126PMID 23112234DOI 10.1093/PROTEIN/GZS078 Variant Set Distributions Ripley’s K Analysis Plots Variant […]

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1AVF.A | PGC

General Structure Information 1avf PGC activation intermediate 2 of human gastricsin from human stomach 2.36Å AUTH A.R.KHAN,M.M.CHERNEY,N.I.TARASOVA,M.N.JAMESTITL STRUCTURAL CHARACTERIZATION OF ACTIVATIONTITL 2 INTERMEDIATE 2 ON THE PATHWAY TO HUMANTITL 3 GASTRICSIN.REF NAT.STRUCT.BIOL. V. 4 1010 1997REFN ISSN 1072-8368PMID 9406551DOI 10.1038/NSB1297-1010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4DVQ.J | CYP11B2

General Structure Information 4dvq CYP11B2 structure of human aldosterone synthase, cyp11b2, in complex with deoxycorticosterone 2.49Å AUTH N.STRUSHKEVICH,A.A.GILEP,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 S.A.USANOV,H.W.PARKTITL STRUCTURAL INSIGHTS INTO ALDOSTERONE SYNTHASE SUBSTRATETITL 2 SPECIFICITY AND TARGETED INHIBITION.REF MOL.ENDOCRINOL. V. 27 315 2013REFN ISSN 0888-8809PMID 23322723DOI 10.1210/ME.2012-1287 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3OWP.A | PRKACA

General Structure Information 3owp PRKACA human camp-dependent protein kinase in complex with an inhibitor 1.88Å AUTH H.KOESTER,T.CRAAN,S.BRASS,A.HEINE,G.KLEBETITL FRAGMENT BASED DRUG DESIGN ON PKAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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4FYS.A | ANPEP

General Structure Information 4fys ANPEP human aminopeptidase n (cd13) in complex with angiotensin iv 2.01Å AUTH A.H.WONG,D.ZHOU,J.M.RINITITL THE X-RAY CRYSTAL STRUCTURE OF HUMAN AMINOPEPTIDASE NTITL 2 REVEALS A NOVEL DIMER AND THE BASIS FOR PEPTIDE PROCESSING.REF J.BIOL.CHEM. V. 287 36804 2012REFN ISSN 0021-9258PMID 22932899DOI 10.1074/JBC.M112.398842 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]

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